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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LGTN All Species: 30.61
Human Site: Y84 Identified Species: 56.11
UniProt: P41214 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41214 NP_008824.2 584 64706 Y84 K N L Y P T V Y T L W S Y P D
Chimpanzee Pan troglodytes XP_514150 683 75708 Y183 K N L Y P T V Y T L W S Y P D
Rhesus Macaque Macaca mulatta XP_001086830 584 64481 Y84 K N L Y P T V Y T L W S Y P D
Dog Lupus familis XP_536109 584 64640 Y84 K N L Y P T V Y T L W S Y P D
Cat Felis silvestris
Mouse Mus musculus Q61211 570 62811 Y84 K N L Y P T V Y T L W A Y P D
Rat Rattus norvegicus Q5PPG7 570 62651 Y84 K N L Y P T V Y T L W S H P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006322 315 34256
Frog Xenopus laevis NP_001090591 583 64871 Y84 R N L Y P T V Y T L W K Y P D
Zebra Danio Brachydanio rerio NP_957456 590 66065 Y84 K Q L F P T V Y T L W R C P N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477481 563 61913 L84 L V P T L Y T L W I V P D I L
Honey Bee Apis mellifera XP_392122 528 58787 P84 S L H Q A L L P T I Y T L W H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177291 597 65656 F84 T E I F P T V F A L W E A P E
Baker's Yeast Sacchar. cerevisiae Q04600 565 63973 E84 P T V Y S C W E Y P A L L P I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.4 97.5 87.5 N.A. 80.9 81.1 N.A. N.A. 33 58.7 56.9 N.A. 35.6 35 N.A. N.A.
Protein Similarity: 100 84.9 98.6 93.6 N.A. 88.8 89.3 N.A. N.A. 43.3 74.3 74.4 N.A. 51.3 55.6 N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 0 86.6 66.6 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 0 93.3 80 N.A. 6.6 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 32.3 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. 52.4 45.3 N.A.
P-Site Identity: N.A. N.A. N.A. 40 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 8 0 8 8 8 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 54 % D
% Glu: 0 8 0 0 0 0 0 8 0 0 0 8 0 0 8 % E
% Phe: 0 0 0 16 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 8 0 8 % H
% Ile: 0 0 8 0 0 0 0 0 0 16 0 0 0 8 8 % I
% Lys: 54 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % K
% Leu: 8 8 62 0 8 8 8 8 0 70 0 8 16 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 54 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 8 0 8 0 70 0 0 8 0 8 0 8 0 77 0 % P
% Gln: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % R
% Ser: 8 0 0 0 8 0 0 0 0 0 0 39 0 0 0 % S
% Thr: 8 8 0 8 0 70 8 0 70 0 0 8 0 0 0 % T
% Val: 0 8 8 0 0 0 70 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 8 0 70 0 0 8 0 % W
% Tyr: 0 0 0 62 0 8 0 62 8 0 8 0 47 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _