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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HNF4A All Species: 18.18
Human Site: S43 Identified Species: 33.33
UniProt: P41235 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41235 NP_849180.1 474 52785 S43 M G N D T S P S E G T N L N A
Chimpanzee Pan troglodytes XP_514664 468 51900 R52 T S L E H I W R G G Q F S T G
Rhesus Macaque Macaca mulatta XP_001110097 452 49945 A46 P N S L G V S A L C A I C G D
Dog Lupus familis XP_852731 474 52640 S43 M G N D T S P S E G A N L N A
Cat Felis silvestris
Mouse Mus musculus P49698 474 52665 S43 M G N D T S P S E G A N L N S
Rat Rattus norvegicus P22449 474 52693 S43 M G N D T S P S E G A N L N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507309 419 46844 D39 Q V L A M G S D V S P S E G V
Chicken Gallus gallus NP_001026026 454 50607 N43 A A N L N T S N S I G V S A L
Frog Xenopus laevis Q91766 464 51948 S43 I G T D T S T S D V T S L S A
Zebra Danio Brachydanio rerio A2T929 430 47452 G43 S V I S S P M G P H S M A S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49866 666 71882 S87 G S G S G T N S S Q Q Q L Q Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O44960 369 41820
Sea Urchin Strong. purpuratus XP_780389 468 51669 S43 G K H Y G A A S C D G C K G F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.6 90.9 98.3 N.A. 95.7 96.1 N.A. 79.5 84.1 80.8 33.7 N.A. 42.4 N.A. 33.9 57.1
Protein Similarity: 100 82.9 91.9 99.1 N.A. 97 97.4 N.A. 84.8 89.8 89.6 51.4 N.A. 54.5 N.A. 49.5 72.3
P-Site Identity: 100 6.6 0 93.3 N.A. 86.6 86.6 N.A. 0 6.6 53.3 0 N.A. 13.3 N.A. 0 6.6
P-Site Similarity: 100 13.3 13.3 93.3 N.A. 93.3 93.3 N.A. 6.6 20 80 20 N.A. 20 N.A. 0 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 8 8 8 0 0 31 0 8 8 24 % A
% Cys: 0 0 0 0 0 0 0 0 8 8 0 8 8 0 0 % C
% Asp: 0 0 0 39 0 0 0 8 8 8 0 0 0 0 8 % D
% Glu: 0 0 0 8 0 0 0 0 31 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % F
% Gly: 16 39 8 0 24 8 0 8 8 39 16 0 0 24 8 % G
% His: 0 0 8 0 8 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 8 0 0 0 8 0 8 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % K
% Leu: 0 0 16 16 0 0 0 0 8 0 0 0 47 0 8 % L
% Met: 31 0 0 0 8 0 8 0 0 0 0 8 0 0 0 % M
% Asn: 0 8 39 0 8 0 8 8 0 0 0 31 0 31 0 % N
% Pro: 8 0 0 0 0 8 31 0 8 0 8 0 0 0 8 % P
% Gln: 8 0 0 0 0 0 0 0 0 8 16 8 0 8 8 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 8 16 8 16 8 39 24 54 16 8 8 16 16 16 16 % S
% Thr: 8 0 8 0 39 16 8 0 0 0 16 0 0 8 0 % T
% Val: 0 16 0 0 0 8 0 0 8 8 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _