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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HNF4A All Species: 22.73
Human Site: S443 Identified Species: 41.67
UniProt: P41235 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41235 NP_849180.1 474 52785 S443 S P P G G S G S E P Y K L L P
Chimpanzee Pan troglodytes XP_514664 468 51900 S437 S P P G G S G S E P Y K L L P
Rhesus Macaque Macaca mulatta XP_001110097 452 49945 S421 S P P G G S G S E P Y K L L P
Dog Lupus familis XP_852731 474 52640 S443 S P P G G S G S E P Y K L L P
Cat Felis silvestris
Mouse Mus musculus P49698 474 52665 S443 S P P S G S G S E S Y K L L P
Rat Rattus norvegicus P22449 474 52693 S443 S P P S G S G S E S Y K L L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507309 419 46844 L389 G P H T H H P L H P H L M Q E
Chicken Gallus gallus NP_001026026 454 50607 P423 S P P A G S G P E Q Y K L L P
Frog Xenopus laevis Q91766 464 51948 A433 S P P A G S G A E Q Y K I V H
Zebra Danio Brachydanio rerio A2T929 430 47452 K399 A L R S I G L K C L E H L F F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49866 666 71882 P575 Y N G S R S G P L P T Q H S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O44960 369 41820 A339 L A K L F G L A S I D N L M L
Sea Urchin Strong. purpuratus XP_780389 468 51669 T436 T H P P A T A T A G P P A P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.6 90.9 98.3 N.A. 95.7 96.1 N.A. 79.5 84.1 80.8 33.7 N.A. 42.4 N.A. 33.9 57.1
Protein Similarity: 100 82.9 91.9 99.1 N.A. 97 97.4 N.A. 84.8 89.8 89.6 51.4 N.A. 54.5 N.A. 49.5 72.3
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 13.3 80 60 6.6 N.A. 26.6 N.A. 6.6 6.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 26.6 80 80 13.3 N.A. 33.3 N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 16 8 0 8 16 8 0 0 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 62 0 8 0 0 0 8 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 8 % F
% Gly: 8 0 8 31 62 16 70 0 0 8 0 0 0 0 0 % G
% His: 0 8 8 0 8 8 0 0 8 0 8 8 8 0 8 % H
% Ile: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 0 % I
% Lys: 0 0 8 0 0 0 0 8 0 0 0 62 0 0 0 % K
% Leu: 8 8 0 8 0 0 16 8 8 8 0 8 70 54 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 0 70 70 8 0 0 8 16 0 47 8 8 0 8 62 % P
% Gln: 0 0 0 0 0 0 0 0 0 16 0 8 0 8 0 % Q
% Arg: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 62 0 0 31 0 70 0 47 8 16 0 0 0 8 0 % S
% Thr: 8 0 0 8 0 8 0 8 0 0 8 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 62 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _