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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IARS All Species: 40.91
Human Site: Y198 Identified Species: 69.23
UniProt: P41252 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41252 NP_002152.2 1262 144498 Y198 N F E S H Q N Y K D V Q D P S
Chimpanzee Pan troglodytes XP_520691 1152 131723 Y179 A Y L K G K K Y R P L F D Y F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_541332 2763 310768 Y1570 N F E S H Q N Y K D V Q D P S
Cat Felis silvestris
Mouse Mus musculus Q8BU30 1262 144238 Y198 N F E S N Q N Y K D V Q D P S
Rat Rattus norvegicus NP_001094042 1262 144267 Y198 N F E S N Q N Y K D V Q D P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512705 1182 134676 E181 E S E Y E I L E K F P G I S L
Chicken Gallus gallus XP_414300 1264 144692 Y198 N F E S H Q N Y K D V Q D P S
Frog Xenopus laevis NP_001084397 1259 143978 Y198 N F E S H Q N Y K D V Q D P S
Zebra Danio Brachydanio rerio NP_956190 1271 145113 Y198 N F E A N Q N Y K D V Q D P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730716 1229 141081 Y206 N F E A N Q N Y K E V V D P C
Honey Bee Apis mellifera XP_624023 1246 144330 Y198 N F E S G Q N Y K D V I D P S
Nematode Worm Caenorhab. elegans Q21926 1141 129993 V174 E L H K K G L V Y K G V K V M
Sea Urchin Strong. purpuratus XP_801899 1186 135049 Y198 N F E S G Q N Y K D V V D P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09436 1072 122965 D105 K L G I T G K D D V F K Y G L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.8 N.A. 40.1 N.A. 90.5 90.7 N.A. 73.6 81.9 77.5 74.1 N.A. 52.8 57.4 52.1 60.3
Protein Similarity: 100 91.1 N.A. 42.8 N.A. 96.5 96.4 N.A. 82.9 91.4 87.6 87.1 N.A. 69.3 73.8 67 74.2
P-Site Identity: 100 13.3 N.A. 100 N.A. 93.3 93.3 N.A. 13.3 100 100 86.6 N.A. 66.6 86.6 0 80
P-Site Similarity: 100 40 N.A. 100 N.A. 100 100 N.A. 13.3 100 100 100 N.A. 86.6 86.6 0 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 47 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 62.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 0 0 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 0 8 8 65 0 0 79 0 0 % D
% Glu: 15 0 79 0 8 0 0 8 0 8 0 0 0 0 0 % E
% Phe: 0 72 0 0 0 0 0 0 0 8 8 8 0 0 8 % F
% Gly: 0 0 8 0 22 15 0 0 0 0 8 8 0 8 0 % G
% His: 0 0 8 0 29 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 8 0 0 0 0 0 8 8 0 0 % I
% Lys: 8 0 0 15 8 8 15 0 79 8 0 8 8 0 0 % K
% Leu: 0 15 8 0 0 0 15 0 0 0 8 0 0 0 15 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 72 0 0 0 29 0 72 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 8 0 0 72 0 % P
% Gln: 0 0 0 0 0 72 0 0 0 0 0 50 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 0 8 0 58 0 0 0 0 0 0 0 0 0 8 58 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 8 0 8 72 22 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 8 0 0 0 79 8 0 0 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _