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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCI
All Species:
26.97
Human Site:
Y125
Identified Species:
42.38
UniProt:
P41743
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41743
NP_002731.4
596
68262
Y125
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Chimpanzee
Pan troglodytes
XP_001148501
597
67369
H131
K
L
Y
C
A
N
G
H
L
F
Q
A
K
R
F
Rhesus Macaque
Macaca mulatta
XP_001089400
597
68263
Y126
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Dog
Lupus familis
XP_535855
696
78257
Y225
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Cat
Felis silvestris
Mouse
Mus musculus
Q62074
595
68185
Y125
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Rat
Rattus norvegicus
P09217
592
67715
R116
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506164
360
41199
Chicken
Gallus gallus
XP_417561
606
69931
Y129
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Frog
Xenopus laevis
NP_001084068
588
67442
Y118
T
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
Y118
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13678
634
71138
L167
C
D
H
C
G
S
L
L
Y
G
L
I
K
Q
G
Honey Bee
Apis mellifera
XP_397273
590
68031
A116
R
S
I
Y
R
R
G
A
R
R
W
R
K
L
Y
Nematode Worm
Caenorhab. elegans
Q19266
597
68017
W119
Y
R
R
G
A
R
R
W
K
K
I
Y
L
Y
N
Sea Urchin
Strong. purpuratus
XP_780275
524
59689
K96
C
K
L
L
V
H
K
K
C
H
R
L
V
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P87253
1142
127954
K442
G
M
D
R
L
G
R
K
G
A
V
R
Q
R
K
Conservation
Percent
Protein Identity:
100
66.6
96.8
84.3
N.A.
98.3
72.3
N.A.
59.9
71.4
89.7
88.7
N.A.
36.4
67.9
58.1
63.5
Protein Similarity:
100
78.5
97.4
84.9
N.A.
98.8
83.5
N.A.
60.4
83
94.4
92.9
N.A.
54
78.1
74.1
72.4
P-Site Identity:
100
13.3
100
100
N.A.
100
13.3
N.A.
0
100
93.3
100
N.A.
6.6
13.3
0
0
P-Site Similarity:
100
40
100
100
N.A.
100
20
N.A.
0
100
93.3
100
N.A.
26.6
33.3
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
23.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
14
0
0
7
0
7
7
54
0
0
0
% A
% Cys:
14
0
0
14
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
7
14
47
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
47
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% F
% Gly:
14
47
0
7
7
7
14
0
7
14
47
0
0
0
7
% G
% His:
0
0
7
0
0
7
0
7
0
7
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
7
47
0
0
0
7
7
0
0
0
% I
% Lys:
7
7
0
7
47
0
7
14
7
7
0
0
20
7
7
% K
% Leu:
0
7
7
7
7
0
7
7
7
0
7
7
7
7
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% N
% Pro:
40
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
7
7
0
% Q
% Arg:
7
7
7
7
7
14
14
7
60
54
7
20
54
60
7
% R
% Ser:
0
7
0
0
7
54
0
0
0
0
0
0
0
0
0
% S
% Thr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
7
0
0
7
47
% W
% Tyr:
7
0
7
7
0
0
7
47
7
0
0
7
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _