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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR1C3
All Species:
21.82
Human Site:
S221
Identified Species:
80
UniProt:
P42330
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42330
NP_003730.4
323
36844
S221
V
A
Y
S
A
L
G
S
Q
R
D
K
R
W
V
Chimpanzee
Pan troglodytes
XP_001142938
323
36990
T221
V
A
H
S
A
L
G
T
Q
R
H
E
L
W
V
Rhesus Macaque
Macaca mulatta
XP_001104543
323
36869
S221
V
A
Y
S
A
L
G
S
Q
R
D
K
R
W
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P70694
323
37029
S221
V
A
Y
S
A
L
G
S
H
R
E
K
Q
W
V
Rat
Rattus norvegicus
P51652
323
37281
T221
V
A
Y
G
A
L
G
T
Q
R
Y
K
Y
C
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511338
324
36611
S222
V
V
Y
S
A
L
G
S
Q
R
D
K
N
W
V
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6AZW2
324
36744
S214
T
A
Y
S
P
L
G
S
P
D
R
P
W
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.6
95.9
N.A.
N.A.
75.8
71.2
N.A.
71.5
N.A.
N.A.
42.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
95
98.1
N.A.
N.A.
89.1
85.7
N.A.
84.5
N.A.
N.A.
63.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
66.6
100
N.A.
N.A.
80
60
N.A.
86.6
N.A.
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
86.6
100
N.A.
N.A.
93.3
73.3
N.A.
86.6
N.A.
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
86
0
0
86
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
15
43
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
15
15
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
15
0
0
100
0
0
0
0
0
0
0
0
% G
% His:
0
0
15
0
0
0
0
0
15
0
15
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
72
0
0
0
% K
% Leu:
0
0
0
0
0
100
0
0
0
0
0
0
15
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% N
% Pro:
0
0
0
0
15
0
0
0
15
0
0
15
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
72
0
0
0
15
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
86
15
0
29
0
0
% R
% Ser:
0
0
0
86
0
0
0
72
0
0
0
0
0
0
0
% S
% Thr:
15
0
0
0
0
0
0
29
0
0
0
0
0
0
15
% T
% Val:
86
15
0
0
0
0
0
0
0
0
0
0
0
15
72
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
15
72
0
% W
% Tyr:
0
0
86
0
0
0
0
0
0
0
15
0
15
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _