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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AKR1C3 All Species: 9.09
Human Site: Y272 Identified Species: 33.33
UniProt: P42330 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42330 NP_003730.4 323 36844 Y272 V V V L A K S Y N E Q R I R Q
Chimpanzee Pan troglodytes XP_001142938 323 36990 Y272 V V V L A K S Y N E Q R I R E
Rhesus Macaque Macaca mulatta XP_001104543 323 36869 Y272 V V V L A K S Y N E Q R I R E
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P70694 323 37029 F272 V V V L A K S F S E K R I K E
Rat Rattus norvegicus P51652 323 37281 F272 I V T L V K S F N E E R I R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511338 324 36611 F273 A V V L V K S F N E K R I K E
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6AZW2 324 36744 V264 V V C I P K S V T P S R I K Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.6 95.9 N.A. N.A. 75.8 71.2 N.A. 71.5 N.A. N.A. 42.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 95 98.1 N.A. N.A. 89.1 85.7 N.A. 84.5 N.A. N.A. 63.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 N.A. N.A. 66.6 60 N.A. 60 N.A. N.A. 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 N.A. N.A. 100 86.6 N.A. 86.6 N.A. N.A. 60 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 0 0 58 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 86 15 0 0 0 72 % E
% Phe: 0 0 0 0 0 0 0 43 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 15 0 0 15 0 0 0 0 0 0 0 0 100 0 0 % I
% Lys: 0 0 0 0 0 100 0 0 0 0 29 0 0 43 0 % K
% Leu: 0 0 0 86 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 72 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 15 0 0 0 0 15 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 43 0 0 0 29 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 100 0 58 0 % R
% Ser: 0 0 0 0 0 0 100 0 15 0 15 0 0 0 0 % S
% Thr: 0 0 15 0 0 0 0 0 15 0 0 0 0 0 0 % T
% Val: 72 100 72 0 29 0 0 15 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 43 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _