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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 18.79
Human Site: S295 Identified Species: 29.52
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 S295 M A K E S L Y S Q L P M D C F
Chimpanzee Pan troglodytes XP_001160550 1044 119347 L283 M V H S S S I L A M R D E Q S
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 Y293 C C K I K K M Y E Q E M I A I
Dog Lupus familis XP_546764 1044 119674 L283 M V H S S S I L A M R D E Q S
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 S295 M A K E S L Y S Q L P I D S F
Rat Rattus norvegicus Q9Z1L0 1070 122589 Y293 C C K I K K M Y E Q E M I A I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 T295 M A K E S L Y T Q L P L D T F
Chicken Gallus gallus NP_001004410 1068 124270 T295 M A K E S L Y T Q L P L D T F
Frog Xenopus laevis Q6AZN6 886 101139 F198 D W L D R L T F R E I E M I N
Zebra Danio Brachydanio rerio XP_690235 1069 124426 S295 M S K D S L Y S Q L P M D N F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 E290 V D Q E N T S E N I E A D T L
Nematode Worm Caenorhab. elegans Q94125 1182 136855 L390 R K L A L D V L S V S I D S T
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 E279 L I L I H K S E L K V E D R F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 K126 T V L L F N S K M Q M K S G K
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 K187 L D E I T I S K L R K Q R E N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 13.3 13.3 13.3 N.A. 86.6 13.3 N.A. 80 80 6.6 80 N.A. N.A. 13.3 6.6 13.3
P-Site Similarity: 100 26.6 20 26.6 N.A. 93.3 20 N.A. 93.3 93.3 20 93.3 N.A. N.A. 40 20 20
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 27 0 7 0 0 0 0 14 0 0 7 0 14 0 % A
% Cys: 14 14 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 7 14 0 14 0 7 0 0 0 0 0 14 54 0 0 % D
% Glu: 0 0 7 34 0 0 0 14 14 7 20 14 14 7 0 % E
% Phe: 0 0 0 0 7 0 0 7 0 0 0 0 0 0 40 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % G
% His: 0 0 14 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 27 0 7 14 0 0 7 7 14 14 7 14 % I
% Lys: 0 7 47 0 14 20 0 14 0 7 7 7 0 0 7 % K
% Leu: 14 0 27 7 7 40 0 20 14 34 0 14 0 0 7 % L
% Met: 47 0 0 0 0 0 14 0 7 14 7 27 7 0 0 % M
% Asn: 0 0 0 0 7 7 0 0 7 0 0 0 0 7 14 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 34 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 34 20 0 7 0 14 0 % Q
% Arg: 7 0 0 0 7 0 0 0 7 7 14 0 7 7 0 % R
% Ser: 0 7 0 14 47 14 27 20 7 0 7 0 7 14 14 % S
% Thr: 7 0 0 0 7 7 7 14 0 0 0 0 0 20 7 % T
% Val: 7 20 0 0 0 0 7 0 0 7 7 0 0 0 0 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 34 14 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _