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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
20.61
Human Site:
S326
Identified Species:
32.38
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S326
N
G
E
T
S
T
K
S
L
W
V
I
N
S
A
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
V314
P
A
K
K
P
S
S
V
S
L
W
S
L
E
Q
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S324
P
K
K
T
R
I
I
S
H
V
W
E
N
N
N
Dog
Lupus familis
XP_546764
1044
119674
L314
P
M
K
K
P
S
S
L
S
L
W
S
L
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S326
N
G
E
T
S
T
K
S
L
W
V
I
N
S
A
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S324
P
K
K
T
R
V
I
S
H
V
W
G
N
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S326
N
G
E
A
S
A
K
S
L
W
V
I
N
S
A
Chicken
Gallus gallus
NP_001004410
1068
124270
S326
N
G
E
A
T
A
K
S
L
W
T
I
N
S
A
Frog
Xenopus laevis
Q6AZN6
886
101139
K229
P
C
V
K
C
D
E
K
E
Y
G
I
V
Y
Y
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S326
N
G
E
A
S
T
K
S
L
W
T
I
N
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
I321
K
H
V
S
A
W
K
I
E
E
P
F
V
F
T
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S421
T
A
S
L
K
Q
V
S
L
W
D
L
D
A
N
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
R310
P
L
P
S
K
A
G
R
Y
V
S
W
D
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
P157
T
S
T
P
G
K
V
P
R
H
E
R
G
E
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
I218
L
E
L
P
V
V
F
I
E
R
E
I
M
N
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
0
20
0
N.A.
100
20
N.A.
86.6
73.3
6.6
80
N.A.
N.A.
6.6
20
0
P-Site Similarity:
100
13.3
33.3
13.3
N.A.
100
33.3
N.A.
86.6
80
20
80
N.A.
N.A.
20
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
0
20
7
20
0
0
0
0
0
0
0
7
27
% A
% Cys:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
0
0
7
0
14
0
0
% D
% Glu:
0
7
34
0
0
0
7
0
20
7
14
7
0
20
7
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% F
% Gly:
0
34
0
0
7
0
7
0
0
0
7
7
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
14
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
14
14
0
0
0
47
0
7
0
% I
% Lys:
7
14
27
20
14
7
40
7
0
0
0
0
0
0
0
% K
% Leu:
7
7
7
7
0
0
0
7
40
14
0
7
14
0
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
34
0
0
0
0
0
0
0
0
0
0
0
47
20
20
% N
% Pro:
40
0
7
14
14
0
0
7
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
14
% Q
% Arg:
0
0
0
0
14
0
0
7
7
7
0
7
0
0
0
% R
% Ser:
0
7
7
14
27
14
14
54
14
0
7
14
0
34
0
% S
% Thr:
14
0
7
27
7
20
0
0
0
0
14
0
0
0
20
% T
% Val:
0
0
14
0
7
14
14
7
0
20
20
0
14
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
40
27
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
7
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _