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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
17.88
Human Site:
S481
Identified Species:
28.1
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S481
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
A468
S
N
P
N
T
D
S
A
A
A
L
L
I
C
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
L491
Y
T
E
N
A
T
A
L
H
I
K
F
P
E
N
Dog
Lupus familis
XP_546764
1044
119674
A468
S
N
P
N
T
E
S
A
A
A
L
V
I
C
L
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S481
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
A490
P
Y
A
E
N
A
T
A
L
H
I
K
F
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S481
E
L
E
F
D
W
F
S
S
P
V
K
F
P
D
Chicken
Gallus gallus
NP_001004410
1068
124270
S481
E
L
E
F
D
W
F
S
N
P
V
K
F
P
D
Frog
Xenopus laevis
Q6AZN6
886
101139
L366
D
V
E
D
S
L
E
L
L
S
S
H
F
T
N
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S481
E
L
E
F
D
Y
F
S
S
P
V
K
F
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y490
L
M
L
T
F
P
N
Y
G
K
E
K
S
V
L
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
I565
G
T
N
A
A
V
T
I
E
I
S
S
Y
G
G
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
V459
D
L
V
P
I
A
W
V
N
L
T
F
F
D
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
P294
I
Q
R
V
L
K
Y
P
P
T
R
T
L
S
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
E355
T
N
L
R
E
E
S
E
R
V
E
V
L
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
0
6.6
0
N.A.
100
20
N.A.
93.3
86.6
13.3
86.6
N.A.
N.A.
6.6
0
13.3
P-Site Similarity:
100
20
20
20
N.A.
100
46.6
N.A.
93.3
93.3
33.3
93.3
N.A.
N.A.
13.3
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
14
14
7
20
14
14
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% C
% Asp:
14
0
0
7
34
7
0
0
0
0
0
0
0
7
34
% D
% Glu:
34
0
47
7
7
14
7
7
7
0
14
0
0
14
7
% E
% Phe:
0
0
0
34
7
0
34
0
0
0
0
14
54
0
0
% F
% Gly:
7
0
0
0
0
0
0
0
7
0
0
0
0
7
14
% G
% His:
0
0
0
0
0
0
0
0
7
7
0
7
0
0
0
% H
% Ile:
7
0
0
0
7
0
0
7
0
14
7
0
14
0
0
% I
% Lys:
0
0
0
0
0
7
0
0
0
7
7
47
0
0
0
% K
% Leu:
7
40
14
0
7
7
0
14
14
7
14
7
14
0
27
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
20
7
20
7
0
7
0
14
0
0
0
0
0
14
% N
% Pro:
7
0
14
7
0
7
0
7
7
20
0
0
7
40
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
7
0
0
0
0
7
0
7
0
0
0
0
% R
% Ser:
14
0
0
0
7
0
20
34
27
7
14
7
7
7
0
% S
% Thr:
7
14
0
7
14
7
14
0
0
7
7
7
0
7
0
% T
% Val:
0
7
7
7
0
7
0
7
0
20
34
14
0
7
0
% V
% Trp:
0
0
0
0
0
27
7
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
7
7
7
0
0
0
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _