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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 17.88
Human Site: S481 Identified Species: 28.1
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 S481 E L E F D W F S S V V K F P D
Chimpanzee Pan troglodytes XP_001160550 1044 119347 A468 S N P N T D S A A A L L I C L
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 L491 Y T E N A T A L H I K F P E N
Dog Lupus familis XP_546764 1044 119674 A468 S N P N T E S A A A L V I C L
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 S481 E L E F D W F S S V V K F P D
Rat Rattus norvegicus Q9Z1L0 1070 122589 A490 P Y A E N A T A L H I K F P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 S481 E L E F D W F S S P V K F P D
Chicken Gallus gallus NP_001004410 1068 124270 S481 E L E F D W F S N P V K F P D
Frog Xenopus laevis Q6AZN6 886 101139 L366 D V E D S L E L L S S H F T N
Zebra Danio Brachydanio rerio XP_690235 1069 124426 S481 E L E F D Y F S S P V K F P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 Y490 L M L T F P N Y G K E K S V L
Nematode Worm Caenorhab. elegans Q94125 1182 136855 I565 G T N A A V T I E I S S Y G G
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 V459 D L V P I A W V N L T F F D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 P294 I Q R V L K Y P P T R T L S G
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 E355 T N L R E E S E R V E V L E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 0 6.6 0 N.A. 100 20 N.A. 93.3 86.6 13.3 86.6 N.A. N.A. 6.6 0 13.3
P-Site Similarity: 100 20 20 20 N.A. 100 46.6 N.A. 93.3 93.3 33.3 93.3 N.A. N.A. 13.3 13.3 40
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 14 14 7 20 14 14 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % C
% Asp: 14 0 0 7 34 7 0 0 0 0 0 0 0 7 34 % D
% Glu: 34 0 47 7 7 14 7 7 7 0 14 0 0 14 7 % E
% Phe: 0 0 0 34 7 0 34 0 0 0 0 14 54 0 0 % F
% Gly: 7 0 0 0 0 0 0 0 7 0 0 0 0 7 14 % G
% His: 0 0 0 0 0 0 0 0 7 7 0 7 0 0 0 % H
% Ile: 7 0 0 0 7 0 0 7 0 14 7 0 14 0 0 % I
% Lys: 0 0 0 0 0 7 0 0 0 7 7 47 0 0 0 % K
% Leu: 7 40 14 0 7 7 0 14 14 7 14 7 14 0 27 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 20 7 20 7 0 7 0 14 0 0 0 0 0 14 % N
% Pro: 7 0 14 7 0 7 0 7 7 20 0 0 7 40 0 % P
% Gln: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 7 7 0 0 0 0 7 0 7 0 0 0 0 % R
% Ser: 14 0 0 0 7 0 20 34 27 7 14 7 7 7 0 % S
% Thr: 7 14 0 7 14 7 14 0 0 7 7 7 0 7 0 % T
% Val: 0 7 7 7 0 7 0 7 0 20 34 14 0 7 0 % V
% Trp: 0 0 0 0 0 27 7 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 0 7 7 7 0 0 0 0 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _