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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 20.91
Human Site: S571 Identified Species: 32.86
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 S571 I L P K L L L S V K W N S R D
Chimpanzee Pan troglodytes XP_001160550 1044 119347 V552 A L A R L L L V T K G T K H E
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 S579 S L P K L L L S I K W N K L E
Dog Lupus familis XP_546764 1044 119674 V552 A L A R L L L V T K W N K H E
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 S571 I L P K L L L S V K W N S R D
Rat Rattus norvegicus Q9Z1L0 1070 122589 S579 S L P K L L L S I K W N K L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 S571 I L P K L L L S V K W N S R D
Chicken Gallus gallus NP_001004410 1068 124270 S571 I L P K L L L S V K W N S R D
Frog Xenopus laevis Q6AZN6 886 101139 P450 Q I L S N P L P A V S S P A P
Zebra Danio Brachydanio rerio XP_690235 1069 124426 A571 I L P K I L L A V K W N S R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 H578 T L L A K L L H C V E W N D H
Nematode Worm Caenorhab. elegans Q94125 1182 136855 A658 L I V L S E L A F V W T D R E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 Q554 Q A L E E L R Q I V E K D P L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 A378 A V S V L E R A D D E E L Q C
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 Q439 I V D A V S S Q K L S G D S M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 33.3 66.6 46.6 N.A. 100 66.6 N.A. 100 100 6.6 86.6 N.A. N.A. 20 20 6.6
P-Site Similarity: 100 46.6 80 60 N.A. 100 80 N.A. 100 100 20 100 N.A. N.A. 26.6 46.6 20
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 7 14 14 0 0 0 20 7 0 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % C
% Asp: 0 0 7 0 0 0 0 0 7 7 0 0 20 7 34 % D
% Glu: 0 0 0 7 7 14 0 0 0 0 20 7 0 0 34 % E
% Phe: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 14 7 % H
% Ile: 40 14 0 0 7 0 0 0 20 0 0 0 0 0 0 % I
% Lys: 0 0 0 47 7 0 0 0 7 60 0 7 27 0 0 % K
% Leu: 7 67 20 7 60 74 80 0 0 7 0 0 7 14 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 7 0 0 0 0 0 0 54 7 0 0 % N
% Pro: 0 0 47 0 0 7 0 7 0 0 0 0 7 7 7 % P
% Gln: 14 0 0 0 0 0 0 14 0 0 0 0 0 7 0 % Q
% Arg: 0 0 0 14 0 0 14 0 0 0 0 0 0 40 0 % R
% Ser: 14 0 7 7 7 7 7 40 0 0 14 7 34 7 0 % S
% Thr: 7 0 0 0 0 0 0 0 14 0 0 14 0 0 0 % T
% Val: 0 14 7 7 7 0 0 14 34 27 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 60 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _