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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
17.88
Human Site:
S66
Identified Species:
28.1
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S66
H
Q
L
L
Q
D
E
S
S
Y
I
F
V
S
V
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
E66
F
H
M
L
S
G
P
E
A
Y
V
F
T
C
I
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
D76
F
N
L
L
M
D
I
D
S
Y
M
F
A
C
V
Dog
Lupus familis
XP_546764
1044
119674
E66
F
H
M
L
S
D
P
E
A
Y
V
F
T
C
V
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T66
H
Q
L
L
Q
D
E
T
S
Y
I
F
V
S
V
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
D76
F
N
L
L
M
D
I
D
S
Y
M
F
A
C
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S66
H
Q
L
L
Q
D
E
S
S
Y
I
F
V
S
V
Chicken
Gallus gallus
NP_001004410
1068
124270
S66
Y
Q
L
L
Q
D
E
S
S
Y
I
F
V
S
V
Frog
Xenopus laevis
Q6AZN6
886
101139
K36
K
R
E
Q
K
S
Y
K
A
V
L
E
D
P
M
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
T66
H
H
L
L
Q
E
E
T
S
Y
I
F
V
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
P67
H
G
T
L
K
D
A
P
S
Y
V
F
S
C
I
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Q133
G
T
Y
S
V
K
P
Q
D
Y
V
F
R
Q
L
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
N67
F
N
L
L
L
D
L
N
F
Y
I
F
Q
C
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L25
L
K
V
K
I
K
S
L
E
G
H
K
P
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
20
46.6
33.3
N.A.
93.3
46.6
N.A.
100
93.3
0
80
N.A.
N.A.
40
13.3
40
P-Site Similarity:
100
46.6
53.3
53.3
N.A.
100
53.3
N.A.
100
100
33.3
93.3
N.A.
N.A.
60
26.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
20
0
0
0
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
40
0
% C
% Asp:
0
0
0
0
0
60
0
14
7
0
0
0
7
0
0
% D
% Glu:
0
0
7
0
0
7
34
14
7
0
0
7
0
0
0
% E
% Phe:
34
0
0
0
0
0
0
0
7
0
0
80
0
0
0
% F
% Gly:
7
7
0
0
0
7
0
0
0
7
0
0
0
0
0
% G
% His:
34
20
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
14
0
0
0
40
0
0
0
20
% I
% Lys:
7
7
0
7
14
14
0
7
0
0
0
7
0
0
0
% K
% Leu:
7
0
54
74
7
0
7
7
0
0
7
0
0
7
14
% L
% Met:
0
0
14
0
14
0
0
0
0
0
14
0
0
0
7
% M
% Asn:
0
20
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
20
7
0
0
0
0
7
7
0
% P
% Gln:
0
27
0
7
34
0
0
7
0
0
0
0
7
7
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% R
% Ser:
0
0
0
7
14
7
7
20
54
0
0
0
7
34
0
% S
% Thr:
0
7
7
0
0
0
0
14
0
0
0
0
14
0
0
% T
% Val:
0
0
7
0
7
0
0
0
0
7
27
0
34
0
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
0
7
0
0
80
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _