KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
22.73
Human Site:
S773
Identified Species:
35.71
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S773
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
D753
V
E
Q
C
T
F
M
D
S
K
M
K
P
L
W
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
D780
V
E
K
C
K
Y
M
D
S
K
M
K
P
L
W
Dog
Lupus familis
XP_546764
1044
119674
D753
V
E
Q
C
T
F
M
D
S
K
M
K
P
L
W
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S773
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
D780
V
E
K
C
R
Y
M
D
S
K
M
K
P
L
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S773
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
Chicken
Gallus gallus
NP_001004410
1068
124270
S773
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
Frog
Xenopus laevis
Q6AZN6
886
101139
E625
A
K
L
Y
F
K
T
E
D
G
G
K
Y
P
V
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S773
L
E
D
C
R
I
M
S
S
A
K
R
P
L
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
D777
I
E
K
C
R
V
M
D
S
K
M
R
P
L
W
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
G861
I
D
K
A
I
V
L
G
S
A
K
R
P
L
M
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S759
L
N
K
C
K
F
M
S
S
K
M
R
P
L
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
P553
L
R
L
T
F
R
T
P
E
E
G
G
S
C
K
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
T614
L
K
I
T
F
K
T
T
L
N
Q
P
Y
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
46.6
46.6
46.6
N.A.
100
53.3
N.A.
100
100
0
93.3
N.A.
N.A.
60
40
60
P-Site Similarity:
100
66.6
73.3
66.6
N.A.
100
73.3
N.A.
100
100
13.3
100
N.A.
N.A.
80
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
0
0
0
0
40
0
0
0
0
0
% A
% Cys:
0
0
0
74
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
7
7
0
0
0
0
34
7
0
0
0
0
0
0
% D
% Glu:
0
67
27
0
0
0
0
7
7
7
0
0
0
0
0
% E
% Phe:
0
0
0
0
20
20
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
7
0
7
14
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
14
0
7
0
7
34
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
14
34
0
14
14
0
0
0
40
40
34
0
0
7
% K
% Leu:
54
0
14
0
0
0
7
0
7
0
0
0
0
80
7
% L
% Met:
0
0
0
0
0
0
74
0
0
0
40
0
0
0
7
% M
% Asn:
0
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
7
80
7
0
% P
% Gln:
0
0
14
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
7
0
0
47
7
0
0
0
0
0
54
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
40
80
0
0
0
7
0
0
% S
% Thr:
0
0
0
14
14
0
20
7
0
0
0
0
0
0
0
% T
% Val:
27
0
0
0
0
14
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
74
% W
% Tyr:
0
0
0
7
0
14
0
0
0
0
0
0
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _