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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
18.18
Human Site:
S874
Identified Species:
28.57
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
S874
K
G
A
L
Q
F
N
S
H
T
L
H
Q
W
L
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
K852
A
A
T
A
A
F
N
K
D
A
L
L
N
W
L
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
K878
A
A
A
A
A
F
N
K
D
A
L
L
N
W
L
Dog
Lupus familis
XP_546764
1044
119674
K852
A
A
T
A
A
F
N
K
D
A
L
L
N
W
L
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
S874
K
G
A
L
Q
F
N
S
H
T
L
H
Q
W
L
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
K878
A
A
T
A
A
F
N
K
D
A
L
L
N
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
S874
K
G
A
L
Q
F
N
S
H
T
L
H
Q
W
L
Chicken
Gallus gallus
NP_001004410
1068
124270
S874
K
G
A
L
Q
F
N
S
H
T
L
H
Q
W
L
Frog
Xenopus laevis
Q6AZN6
886
101139
Y706
I
Q
N
F
F
R
K
Y
S
P
S
E
K
G
P
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
S874
K
G
A
L
Q
F
N
S
T
T
L
H
Q
W
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
G876
A
T
A
A
F
R
R
G
S
L
L
A
W
L
K
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K990
K
S
K
K
D
S
T
K
N
P
I
E
K
K
I
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
A859
L
T
A
A
F
Q
K
A
A
L
F
E
W
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
K634
S
I
T
S
Y
L
Q
K
F
H
P
D
E
H
A
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
H695
I
L
G
Y
L
K
L
H
Y
P
D
E
N
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
33.3
40
33.3
N.A.
100
33.3
N.A.
100
100
0
93.3
N.A.
N.A.
13.3
6.6
6.6
P-Site Similarity:
100
33.3
40
33.3
N.A.
100
33.3
N.A.
100
100
6.6
93.3
N.A.
N.A.
13.3
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
27
54
40
27
0
0
7
7
27
0
7
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
27
0
7
7
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
27
7
0
0
% E
% Phe:
0
0
0
7
20
60
0
0
7
0
7
0
0
0
0
% F
% Gly:
0
34
7
0
0
0
0
7
0
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
7
27
7
0
34
0
7
0
% H
% Ile:
14
7
0
0
0
0
0
0
0
0
7
0
0
0
7
% I
% Lys:
40
0
7
7
0
7
14
40
0
0
0
0
14
7
14
% K
% Leu:
7
7
0
34
7
7
7
0
0
14
67
27
0
14
60
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
60
0
7
0
0
0
34
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
20
7
0
0
0
7
% P
% Gln:
0
7
0
0
34
7
7
0
0
0
0
0
34
0
0
% Q
% Arg:
0
0
0
0
0
14
7
0
0
0
0
0
0
0
0
% R
% Ser:
7
7
0
7
0
7
0
34
14
0
7
0
0
0
0
% S
% Thr:
0
14
27
0
0
0
7
0
7
34
0
0
0
0
7
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
14
60
0
% W
% Tyr:
0
0
0
7
7
0
0
7
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _