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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 20
Human Site: S919 Identified Species: 31.43
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.5
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 S919 G I G D R H N S N I M V K D D
Chimpanzee Pan troglodytes XP_001160550 1044 119347 D897 G I G D R H S D N I M I R E S
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 D923 G I G D R H S D N I M V K K T
Dog Lupus familis XP_546764 1044 119674 D897 G I G D R H S D N I M I R E N
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 S919 G I G D R H N S N I M V K D D
Rat Rattus norvegicus Q9Z1L0 1070 122589 D923 G I G D R H S D N I M V K K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 S919 G I G D R H N S N I M V K D D
Chicken Gallus gallus NP_001004410 1068 124270 S919 G I G D R H N S N I M V K D D
Frog Xenopus laevis Q6AZN6 886 101139 T751 H L D N L L L T K T G K L F H
Zebra Danio Brachydanio rerio XP_690235 1069 124426 S919 G I G D R H N S N I M V K D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 D921 G I A D R H S D N I M V K K T
Nematode Worm Caenorhab. elegans Q94125 1182 136855 D1035 G I K D R H S D N L M L T E D
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 D904 G I G D R H N D N I M V K E S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 L679 R H L D N L L L T D D G R L F
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 T740 H L D N L L V T P D G H F F H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 60 73.3 60 N.A. 100 73.3 N.A. 100 100 0 100 N.A. N.A. 66.6 53.3 80
P-Site Similarity: 100 86.6 80 93.3 N.A. 100 80 N.A. 100 100 20 100 N.A. N.A. 73.3 80 86.6
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 14 87 0 0 0 47 0 14 7 0 0 34 40 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 27 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 14 7 % F
% Gly: 80 0 67 0 0 0 0 0 0 0 14 7 0 0 0 % G
% His: 14 7 0 0 0 80 0 0 0 0 0 7 0 0 14 % H
% Ile: 0 80 0 0 0 0 0 0 0 74 0 14 0 0 0 % I
% Lys: 0 0 7 0 0 0 0 0 7 0 0 7 60 20 0 % K
% Leu: 0 14 7 0 14 20 14 7 0 7 0 7 7 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 80 0 0 0 0 % M
% Asn: 0 0 0 14 7 0 40 0 80 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 0 0 80 0 0 0 0 0 0 0 20 0 0 % R
% Ser: 0 0 0 0 0 0 40 34 0 0 0 0 0 0 14 % S
% Thr: 0 0 0 0 0 0 0 14 7 7 0 0 7 0 20 % T
% Val: 0 0 0 0 0 0 7 0 0 0 0 60 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _