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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 18.18
Human Site: T229 Identified Species: 28.57
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 T229 A E A I R K K T R S M L L S S
Chimpanzee Pan troglodytes XP_001160550 1044 119347 A218 D V P L A L M A C A L R K K A
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 E225 M N P I K V N E L A I Q K R L
Dog Lupus familis XP_546764 1044 119674 A218 D V P L A L M A C A L R K K A
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 T229 A E A I R K K T R S M L L S S
Rat Rattus norvegicus Q9Z1L0 1070 122589 E225 L N P I K I N E L A I Q K R L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 T229 A E A I R K K T R S M L L S S
Chicken Gallus gallus NP_001004410 1068 124270 T229 A E A I R K K T R S M L L S S
Frog Xenopus laevis Q6AZN6 886 101139 G134 V S L F G K Y G M F R Q G M H
Zebra Danio Brachydanio rerio XP_690235 1069 124426 T229 A E A I R K K T R S M L L S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 L217 H S T T P Y Q L L V S I L N K
Nematode Worm Caenorhab. elegans Q94125 1182 136855 G324 G W F L Q L A G R T T F V T N
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 D210 K S M E K A E D L V E K A Q K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 P62 A L Y I D G A P F G L P M R T
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 F123 G S K Q I P F F N L E T S I F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 0 6.6 0 N.A. 100 6.6 N.A. 100 100 6.6 93.3 N.A. N.A. 6.6 6.6 0
P-Site Similarity: 100 26.6 26.6 26.6 N.A. 100 26.6 N.A. 100 100 6.6 100 N.A. N.A. 26.6 46.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 34 0 14 7 14 14 0 27 0 0 7 0 20 % A
% Cys: 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 % C
% Asp: 14 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % D
% Glu: 0 34 0 7 0 0 7 14 0 0 14 0 0 0 0 % E
% Phe: 0 0 7 7 0 0 7 7 7 7 0 7 0 0 7 % F
% Gly: 14 0 0 0 7 7 0 14 0 7 0 0 7 0 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % H
% Ile: 0 0 0 54 7 7 0 0 0 0 14 7 0 7 0 % I
% Lys: 7 0 7 0 20 40 34 0 0 0 0 7 27 14 14 % K
% Leu: 7 7 7 20 0 20 0 7 27 7 20 34 40 0 14 % L
% Met: 7 0 7 0 0 0 14 0 7 0 34 0 7 7 0 % M
% Asn: 0 14 0 0 0 0 14 0 7 0 0 0 0 7 7 % N
% Pro: 0 0 27 0 7 7 0 7 0 0 0 7 0 0 0 % P
% Gln: 0 0 0 7 7 0 7 0 0 0 0 20 0 7 0 % Q
% Arg: 0 0 0 0 34 0 0 0 40 0 7 14 0 20 0 % R
% Ser: 0 27 0 0 0 0 0 0 0 34 7 0 7 34 27 % S
% Thr: 0 0 7 7 0 0 0 34 0 7 7 7 0 7 7 % T
% Val: 7 14 0 0 0 7 0 0 0 14 0 0 7 0 0 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 7 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _