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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 16.97
Human Site: T303 Identified Species: 26.67
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 T303 Q L P M D C F T M P S Y S R R
Chimpanzee Pan troglodytes XP_001160550 1044 119347 N291 A M R D E Q S N P A P Q V Q K
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 E301 E Q E M I A I E A A I N R N S
Dog Lupus familis XP_546764 1044 119674 N291 A M R D E Q S N P A P Q V Q K
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 T303 Q L P I D S F T M P S Y S R R
Rat Rattus norvegicus Q9Z1L0 1070 122589 E301 E Q E M I A I E A A I N R N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 T303 Q L P L D T F T M P S Y S R R
Chicken Gallus gallus NP_001004410 1068 124270 T303 Q L P L D T F T M P S Y S R R
Frog Xenopus laevis Q6AZN6 886 101139 E206 R E I E M I N E S E K R S S N
Zebra Danio Brachydanio rerio XP_690235 1069 124426 T303 Q L P M D N F T M P S Y S R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 Q298 N I E A D T L Q R T R P S F S
Nematode Worm Caenorhab. elegans Q94125 1182 136855 P398 S V S I D S T P K Q S K N S D
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 K287 L K V E D R F K D P M F N V L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 Q134 M Q M K S G K Q K L R L W Q G
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 R195 L R K Q R E N R T W P Q G T F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 0 6.6 0 N.A. 86.6 6.6 N.A. 86.6 86.6 6.6 93.3 N.A. N.A. 13.3 13.3 20
P-Site Similarity: 100 26.6 13.3 26.6 N.A. 93.3 13.3 N.A. 93.3 93.3 13.3 93.3 N.A. N.A. 20 33.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 0 7 0 14 0 0 14 27 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 14 54 0 0 0 7 0 0 0 0 0 7 % D
% Glu: 14 7 20 14 14 7 0 20 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 40 0 0 0 0 7 0 7 7 % F
% Gly: 0 0 0 0 0 7 0 0 0 0 0 0 7 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 7 14 14 7 14 0 0 0 14 0 0 0 0 % I
% Lys: 0 7 7 7 0 0 7 7 14 0 7 7 0 0 14 % K
% Leu: 14 34 0 14 0 0 7 0 0 7 0 7 0 0 7 % L
% Met: 7 14 7 27 7 0 0 0 34 0 7 0 0 0 0 % M
% Asn: 7 0 0 0 0 7 14 14 0 0 0 14 14 14 7 % N
% Pro: 0 0 34 0 0 0 0 7 14 40 20 7 0 0 0 % P
% Gln: 34 20 0 7 0 14 0 14 0 7 0 20 0 20 0 % Q
% Arg: 7 7 14 0 7 7 0 7 7 0 14 7 14 34 34 % R
% Ser: 7 0 7 0 7 14 14 0 7 0 40 0 47 14 20 % S
% Thr: 0 0 0 0 0 20 7 34 7 7 0 0 0 7 0 % T
% Val: 0 7 7 0 0 0 0 0 0 0 0 0 14 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 34 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _