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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
29.09
Human Site:
T373
Identified Species:
45.71
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
T373
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S361
L
C
K
T
V
S
S
S
E
V
S
V
C
S
E
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S371
L
C
K
T
I
V
S
S
E
V
S
G
K
N
D
Dog
Lupus familis
XP_546764
1044
119674
S361
L
C
K
T
V
S
S
S
E
V
S
V
C
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T373
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S371
L
C
K
T
V
V
S
S
E
I
S
G
K
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T373
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Chicken
Gallus gallus
NP_001004410
1068
124270
T373
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Frog
Xenopus laevis
Q6AZN6
886
101139
S276
K
H
H
K
L
A
R
S
L
R
S
G
P
S
D
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
T373
Q
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
T368
E
S
Q
K
T
K
E
T
V
V
N
S
D
G
S
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
T468
T
L
A
S
K
S
T
T
K
V
N
A
Q
F
A
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S357
E
L
C
P
F
F
T
S
K
E
V
Q
G
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
H204
K
E
Q
E
S
T
K
H
G
S
S
H
L
F
V
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
K265
D
K
Y
H
S
T
L
K
F
Y
D
P
D
Q
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
13.3
6.6
13.3
N.A.
100
6.6
N.A.
100
100
13.3
93.3
N.A.
N.A.
6.6
13.3
20
P-Site Similarity:
100
33.3
40
33.3
N.A.
100
40
N.A.
100
100
26.6
93.3
N.A.
N.A.
13.3
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
7
0
0
0
0
0
7
0
0
7
% A
% Cys:
0
27
40
0
0
0
0
0
0
0
0
0
47
0
0
% C
% Asp:
7
0
0
34
0
0
0
0
0
0
7
0
14
0
27
% D
% Glu:
14
7
0
7
0
0
7
0
27
7
0
0
0
0
14
% E
% Phe:
0
0
0
0
7
7
0
0
7
0
0
0
0
14
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
20
7
7
0
% G
% His:
0
7
7
7
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% I
% Lys:
14
7
27
14
7
7
7
7
14
0
0
0
14
0
0
% K
% Leu:
27
47
0
0
7
0
7
0
7
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
34
0
34
0
0
0
14
0
0
14
34
% N
% Pro:
27
0
0
7
0
0
0
0
0
0
0
40
7
7
7
% P
% Gln:
7
0
14
0
0
0
0
0
34
0
0
7
7
7
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
40
0
0
0
0
0
% R
% Ser:
0
7
0
7
14
20
27
40
0
7
40
7
0
54
7
% S
% Thr:
7
0
0
27
7
14
14
47
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
20
47
0
0
7
34
40
14
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _