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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
22.42
Human Site:
T659
Identified Species:
35.24
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
A639
F
L
L
D
R
A
L
A
N
R
K
I
G
H
F
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
G666
F
L
L
E
R
A
L
G
N
R
R
I
G
Q
F
Dog
Lupus familis
XP_546764
1044
119674
A639
F
L
L
D
R
A
L
A
N
R
K
I
G
H
F
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
D666
F
L
L
E
R
A
L
D
N
R
R
I
G
Q
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Chicken
Gallus gallus
NP_001004410
1068
124270
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Frog
Xenopus laevis
Q6AZN6
886
101139
G530
F
S
Q
A
L
L
K
G
D
K
S
V
R
V
M
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
T659
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
N666
F
L
L
R
R
A
L
N
N
R
R
I
G
H
F
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
C746
M
L
L
T
R
A
L
C
D
Y
R
I
G
H
R
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S644
F
L
L
D
R
A
L
S
N
Q
R
I
G
H
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
N458
I
K
L
P
P
G
V
N
G
E
D
G
Y
Q
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
F519
L
D
Q
I
L
S
S
F
W
S
R
L
D
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
66.6
66.6
66.6
N.A.
100
66.6
N.A.
100
100
6.6
100
N.A.
N.A.
73.3
53.3
80
P-Site Similarity:
100
86.6
86.6
86.6
N.A.
100
86.6
N.A.
100
100
26.6
100
N.A.
N.A.
93.3
66.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
80
0
14
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
20
0
0
0
7
14
0
7
0
7
0
0
% D
% Glu:
0
0
0
14
0
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
80
0
0
0
0
0
0
7
0
0
0
0
0
0
74
% F
% Gly:
0
0
0
0
0
7
0
14
7
0
0
7
80
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% H
% Ile:
7
0
0
7
0
0
0
0
0
0
0
80
0
0
0
% I
% Lys:
0
7
0
34
34
0
7
0
0
7
14
0
0
7
7
% K
% Leu:
7
80
87
0
14
7
80
0
0
0
0
7
0
0
7
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
14
74
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
14
0
0
0
0
0
0
40
0
0
0
20
0
% Q
% Arg:
0
0
0
7
47
0
0
0
0
34
74
0
7
0
7
% R
% Ser:
0
7
0
0
0
7
7
7
0
7
7
0
0
0
0
% S
% Thr:
0
0
0
7
0
0
0
34
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _