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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 29.09
Human Site: T86 Identified Species: 45.71
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 T86 R E E F F D E T R R L C D L R
Chimpanzee Pan troglodytes XP_001160550 1044 119347 Q86 Q Q E L E D E Q R R L C D V Q
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 T96 Y E E L E D E T R R L C D V R
Dog Lupus familis XP_546764 1044 119674 Q86 Q Q E L E D E Q R R L C D I Q
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 T86 R E E F F D E T R R L C D L R
Rat Rattus norvegicus Q9Z1L0 1070 122589 T96 Y E E L E D E T R R L C D V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 T86 R E E F F D E T R R L C D L R
Chicken Gallus gallus NP_001004410 1068 124270 T86 R E E F F D E T R R L C D L R
Frog Xenopus laevis Q6AZN6 886 101139 D56 L Y Q E T C S D L Y V T C Q V
Zebra Danio Brachydanio rerio XP_690235 1069 124426 T86 R E E F Y D E T R R L C D L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 T87 A E E L R D E T R R L C D I K
Nematode Worm Caenorhab. elegans Q94125 1182 136855 D153 I E V I F N D D Q P L S K L E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 K87 Q E E L L D E K R R L C D I K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 L45 I L N P E L M L I G S N V F P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 53.3 73.3 53.3 N.A. 100 73.3 N.A. 100 100 0 93.3 N.A. N.A. 66.6 26.6 60
P-Site Similarity: 100 80 80 80 N.A. 100 80 N.A. 100 100 13.3 100 N.A. N.A. 80 46.6 80
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 74 7 0 0 % C
% Asp: 0 0 0 0 0 74 7 14 0 0 0 0 74 0 0 % D
% Glu: 0 67 74 7 34 0 74 0 0 0 0 0 0 0 7 % E
% Phe: 0 0 0 34 34 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 14 0 0 7 0 0 0 0 7 0 0 0 0 20 0 % I
% Lys: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 14 % K
% Leu: 7 7 0 40 7 7 0 7 7 0 80 0 0 40 0 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 7 0 0 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 7 % P
% Gln: 20 14 7 0 0 0 0 14 7 0 0 0 0 7 14 % Q
% Arg: 34 0 0 0 7 0 0 0 74 74 0 0 0 0 47 % R
% Ser: 0 0 0 0 0 0 7 0 0 0 7 7 0 0 0 % S
% Thr: 0 0 0 0 7 0 0 54 0 0 0 7 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 0 0 7 0 7 20 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 14 7 0 0 7 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _