Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 28.18
Human Site: T974 Identified Species: 44.29
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 T974 G A Q E C T K T R E F E R F Q
Chimpanzee Pan troglodytes XP_001160550 1044 119347 S950 Q Q G K T N N S E K F E R F R
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 T976 Q Q G K T G N T E K F G R F R
Dog Lupus familis XP_546764 1044 119674 S950 Q Q G K T N N S E K F E R F R
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 T974 G A Q E Y T K T R E F E R F Q
Rat Rattus norvegicus Q9Z1L0 1070 122589 T976 Q Q G K T G N T E K F G R F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 T974 G A Q E C T K T R E F E R F Q
Chicken Gallus gallus NP_001004410 1068 124270 T974 G A Q E C T K T R E F E R F Q
Frog Xenopus laevis Q6AZN6 886 101139 Q793 M G G T Q S E Q Y Q A F R K Q
Zebra Danio Brachydanio rerio XP_690235 1069 124426 T975 G T Q E C T K T R E F E R F Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 A976 G Q T K K G Q A V E F Q R F Q
Nematode Worm Caenorhab. elegans Q94125 1182 136855 S1082 H F M T V I R S G K S V D G N
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 T950 H D F V H V I T R G K G A S T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 Q721 A M G G A E S Q Y Y T R F K S
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 N782 F G G A E S S N Y D K F R S Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 26.6 26.6 26.6 N.A. 93.3 26.6 N.A. 100 100 13.3 93.3 N.A. N.A. 40 0 13.3
P-Site Similarity: 100 53.3 46.6 53.3 N.A. 93.3 46.6 N.A. 100 100 33.3 93.3 N.A. N.A. 60 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 27 0 7 7 0 0 7 0 0 7 0 7 0 0 % A
% Cys: 0 0 0 0 27 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % D
% Glu: 0 0 0 34 7 7 7 0 27 40 0 47 0 0 0 % E
% Phe: 7 7 7 0 0 0 0 0 0 0 67 14 7 67 0 % F
% Gly: 40 14 47 7 0 20 0 0 7 7 0 20 0 7 0 % G
% His: 14 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 7 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 34 7 0 34 0 0 34 14 0 0 14 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 7 7 7 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 14 27 7 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 27 34 34 0 7 0 7 14 0 7 0 7 0 0 47 % Q
% Arg: 0 0 0 0 0 0 7 0 40 0 0 7 80 0 27 % R
% Ser: 0 0 0 0 0 14 14 20 0 0 7 0 0 14 7 % S
% Thr: 0 7 7 14 27 34 0 54 0 0 7 0 0 0 7 % T
% Val: 0 0 0 7 7 7 0 0 7 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 20 7 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _