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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 18.18
Human Site: Y165 Identified Species: 28.57
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 Y165 S P H S R A M Y V Y P P N V E
Chimpanzee Pan troglodytes XP_001160550 1044 119347 H126 L L I G K G L H E F D S L C D
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 G131 S K I G V L I G K G L H E F D
Dog Lupus familis XP_546764 1044 119674 G122 S Q I S L L I G K G L H E F D
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 Y165 S P H S R A M Y V Y P P N V E
Rat Rattus norvegicus Q9Z1L0 1070 122589 L140 G L H E F D A L K D P E V N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 Y165 A P H S R A L Y V Y P P N V E
Chicken Gallus gallus NP_001004410 1068 124270 Y165 A P H S R A L Y V C P P N V E
Frog Xenopus laevis Q6AZN6 886 101139 Y78 A L P V R T S Y K A F S T R W
Zebra Danio Brachydanio rerio XP_690235 1069 124426 Y165 G A H S R A L Y V Y P P N V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 R117 S D R N L D S R I G V L I G K
Nematode Worm Caenorhab. elegans Q94125 1182 136855 F263 A K L S Y Q M F W R K R K A E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 H138 M M K N Q E V H D F R S N M K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 R67 L Q V F D K E R N R N L T L P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 0 6.6 13.3 N.A. 100 20 N.A. 86.6 80 13.3 80 N.A. N.A. 6.6 20 6.6
P-Site Similarity: 100 33.3 20 26.6 N.A. 100 20 N.A. 100 93.3 20 86.6 N.A. N.A. 26.6 33.3 53.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 7 0 0 0 34 7 0 0 7 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % C
% Asp: 0 7 0 0 7 14 0 0 7 7 7 0 0 0 20 % D
% Glu: 0 0 0 7 0 7 7 0 7 0 0 7 14 0 47 % E
% Phe: 0 0 0 7 7 0 0 7 0 14 7 0 0 14 0 % F
% Gly: 14 0 0 14 0 7 0 14 0 20 0 0 0 7 0 % G
% His: 0 0 40 0 0 0 0 14 0 0 0 14 0 0 0 % H
% Ile: 0 0 20 0 0 0 14 0 7 0 0 0 7 0 0 % I
% Lys: 0 14 7 0 7 7 0 0 27 0 7 0 7 0 14 % K
% Leu: 14 20 7 0 14 14 27 7 0 0 14 14 7 7 0 % L
% Met: 7 7 0 0 0 0 20 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 14 0 0 0 0 7 0 7 0 40 7 0 % N
% Pro: 0 27 7 0 0 0 0 0 0 0 40 34 0 0 7 % P
% Gln: 0 14 0 0 7 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 7 0 40 0 0 14 0 14 7 7 0 7 0 % R
% Ser: 34 0 0 47 0 0 14 0 0 0 0 20 0 0 0 % S
% Thr: 0 0 0 0 0 7 0 0 0 0 0 0 14 0 0 % T
% Val: 0 0 7 7 7 0 7 0 34 0 7 0 7 34 0 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 7 0 0 40 0 27 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _