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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
17.88
Human Site:
Y182
Identified Species:
28.1
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y182
P
E
L
P
K
H
I
Y
N
K
L
D
K
G
Q
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
M143
V
N
D
F
R
A
K
M
C
Q
F
C
E
E
A
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
F148
K
D
P
E
V
N
E
F
R
R
K
M
R
K
F
Dog
Lupus familis
XP_546764
1044
119674
F139
R
D
P
E
V
N
D
F
R
T
K
M
R
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y182
P
E
L
P
K
H
I
Y
N
K
L
D
K
G
Q
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
E157
R
K
M
R
K
F
S
E
D
K
I
Q
S
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y182
P
E
L
P
K
H
I
Y
N
K
L
D
K
G
Q
Chicken
Gallus gallus
NP_001004410
1068
124270
Y182
P
E
L
P
K
H
I
Y
N
K
L
D
K
G
Q
Frog
Xenopus laevis
Q6AZN6
886
101139
V95
N
E
W
L
K
L
P
V
K
Y
A
D
L
P
R
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y182
P
E
L
P
K
H
I
Y
G
K
L
D
K
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
N134
H
E
F
T
A
L
R
N
S
E
V
N
D
F
R
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K280
G
V
C
E
K
M
M
K
I
Q
I
E
F
N
P
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
H155
C
M
S
V
Q
K
A
H
M
K
W
P
W
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
E23
S
P
V
T
F
R
I
E
K
L
D
G
N
L
P
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
N84
T
P
Y
I
P
F
R
N
S
R
T
W
D
Y
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
0
0
0
N.A.
100
13.3
N.A.
100
100
20
93.3
N.A.
N.A.
6.6
6.6
6.6
P-Site Similarity:
100
20
33.3
26.6
N.A.
100
40
N.A.
100
100
26.6
93.3
N.A.
N.A.
40
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
7
0
0
0
7
0
0
0
7
% A
% Cys:
7
0
7
0
0
0
0
0
7
0
0
7
0
0
0
% C
% Asp:
0
14
7
0
0
0
7
0
7
0
7
40
14
7
0
% D
% Glu:
0
47
0
20
0
0
7
14
0
7
0
7
7
7
0
% E
% Phe:
0
0
7
7
7
14
0
14
0
0
7
0
7
7
14
% F
% Gly:
7
0
0
0
0
0
0
0
7
0
0
7
0
34
0
% G
% His:
7
0
0
0
0
34
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
40
0
7
0
14
0
0
0
0
% I
% Lys:
7
7
0
0
54
7
7
7
14
47
14
0
34
7
7
% K
% Leu:
0
0
34
7
0
14
0
0
0
7
34
0
7
14
0
% L
% Met:
0
7
7
0
0
7
7
7
7
0
0
14
0
0
0
% M
% Asn:
7
7
0
0
0
14
0
14
27
0
0
7
7
7
0
% N
% Pro:
34
14
14
34
7
0
7
0
0
0
0
7
0
7
14
% P
% Gln:
0
0
0
0
7
0
0
0
0
14
0
7
0
7
34
% Q
% Arg:
14
0
0
7
7
7
14
0
14
14
0
0
14
0
14
% R
% Ser:
7
0
7
0
0
0
7
0
14
0
0
0
7
0
0
% S
% Thr:
7
0
0
14
0
0
0
0
0
7
7
0
0
0
0
% T
% Val:
7
7
7
7
14
0
0
7
0
0
7
0
0
0
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
7
7
7
0
7
% W
% Tyr:
0
0
7
0
0
0
0
34
0
7
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _