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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
20.91
Human Site:
Y207
Identified Species:
32.86
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
G198
L
V
N
V
K
F
E
G
S
E
E
S
F
T
F
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
T175
W
M
D
W
L
K
Q
T
Y
P
P
E
H
E
P
Dog
Lupus familis
XP_546764
1044
119674
G198
L
V
N
V
K
F
E
G
S
E
E
S
F
T
F
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S183
Y
P
P
E
H
E
P
S
V
L
E
N
L
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Chicken
Gallus gallus
NP_001004410
1068
124270
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Frog
Xenopus laevis
Q6AZN6
886
101139
K118
W
D
V
Y
G
P
G
K
A
I
P
V
G
G
A
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y207
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
W160
M
A
R
Q
K
K
S
W
M
E
K
V
R
Y
Q
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
L305
F
L
Y
E
M
R
K
L
D
V
Y
D
T
D
D
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
L184
P
N
N
L
P
E
N
L
L
I
N
M
R
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
K46
V
V
S
I
A
E
E
K
K
P
E
L
Y
I
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L107
Q
L
T
F
S
S
H
L
R
I
I
L
W
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
13.3
0
13.3
N.A.
100
13.3
N.A.
100
100
0
100
N.A.
N.A.
13.3
13.3
20
P-Site Similarity:
100
33.3
26.6
33.3
N.A.
100
33.3
N.A.
100
100
20
100
N.A.
N.A.
40
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
0
0
0
7
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
34
0
0
0
0
7
0
0
7
0
7
47
% D
% Glu:
0
0
0
14
0
20
20
0
0
20
27
7
0
20
7
% E
% Phe:
7
0
0
7
0
14
0
0
0
0
0
0
14
7
14
% F
% Gly:
0
0
0
0
7
0
7
14
0
0
0
0
7
7
0
% G
% His:
0
0
0
0
7
0
7
0
0
0
0
0
7
34
0
% H
% Ile:
0
0
0
7
0
0
0
0
0
20
7
34
0
7
0
% I
% Lys:
0
0
0
0
54
14
40
14
7
0
40
0
0
0
0
% K
% Leu:
14
14
0
7
7
0
0
20
7
40
0
14
7
0
0
% L
% Met:
7
7
0
0
7
0
0
0
7
0
0
7
0
0
0
% M
% Asn:
0
40
54
0
0
0
7
0
0
0
7
7
34
0
0
% N
% Pro:
40
7
7
0
7
7
7
0
0
14
14
0
0
0
7
% P
% Gln:
7
0
0
7
0
34
7
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
7
0
0
7
0
0
7
0
0
0
14
0
0
% R
% Ser:
0
0
7
0
7
7
7
7
14
0
0
14
0
0
7
% S
% Thr:
0
0
7
0
0
0
0
7
34
0
0
0
7
14
0
% T
% Val:
7
20
7
14
0
0
0
0
7
7
0
14
0
0
0
% V
% Trp:
14
0
0
7
0
0
0
7
0
0
0
0
7
0
0
% W
% Tyr:
7
0
7
7
0
0
0
34
7
0
7
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _