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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
21.82
Human Site:
Y294
Identified Species:
34.29
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y294
L
M
A
K
E
S
L
Y
S
Q
L
P
M
D
C
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
I282
T
M
V
H
S
S
S
I
L
A
M
R
D
E
Q
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
M292
E
C
C
K
I
K
K
M
Y
E
Q
E
M
I
A
Dog
Lupus familis
XP_546764
1044
119674
I282
T
M
V
H
S
S
S
I
L
A
M
R
D
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y294
L
M
A
K
E
S
L
Y
S
Q
L
P
I
D
S
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
M292
E
C
C
K
I
K
K
M
Y
E
Q
E
M
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y294
L
M
A
K
E
S
L
Y
T
Q
L
P
L
D
T
Chicken
Gallus gallus
NP_001004410
1068
124270
Y294
L
M
A
K
E
S
L
Y
T
Q
L
P
L
D
T
Frog
Xenopus laevis
Q6AZN6
886
101139
T197
V
D
W
L
D
R
L
T
F
R
E
I
E
M
I
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y294
L
M
S
K
D
S
L
Y
S
Q
L
P
M
D
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
S289
S
V
D
Q
E
N
T
S
E
N
I
E
A
D
T
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
V389
E
R
K
L
A
L
D
V
L
S
V
S
I
D
S
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S278
E
L
I
L
I
H
K
S
E
L
K
V
E
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
S125
A
T
V
L
L
F
N
S
K
M
Q
M
K
S
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S186
W
L
D
E
I
T
I
S
K
L
R
K
Q
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
13.3
13.3
13.3
N.A.
86.6
13.3
N.A.
80
80
6.6
80
N.A.
N.A.
13.3
6.6
6.6
P-Site Similarity:
100
26.6
20
26.6
N.A.
93.3
20
N.A.
93.3
93.3
26.6
93.3
N.A.
N.A.
40
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
27
0
7
0
0
0
0
14
0
0
7
0
14
% A
% Cys:
0
14
14
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
7
14
0
14
0
7
0
0
0
0
0
14
54
0
% D
% Glu:
27
0
0
7
34
0
0
0
14
14
7
20
14
14
7
% E
% Phe:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
14
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
27
0
7
14
0
0
7
7
14
14
7
% I
% Lys:
0
0
7
47
0
14
20
0
14
0
7
7
7
0
0
% K
% Leu:
34
14
0
27
7
7
40
0
20
14
34
0
14
0
0
% L
% Met:
0
47
0
0
0
0
0
14
0
7
14
7
27
7
0
% M
% Asn:
0
0
0
0
0
7
7
0
0
7
0
0
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
34
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
34
20
0
7
0
14
% Q
% Arg:
0
7
0
0
0
7
0
0
0
7
7
14
0
7
7
% R
% Ser:
7
0
7
0
14
47
14
27
20
7
0
7
0
7
14
% S
% Thr:
14
7
0
0
0
7
7
7
14
0
0
0
0
0
20
% T
% Val:
7
7
20
0
0
0
0
7
0
0
7
7
0
0
0
% V
% Trp:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
34
14
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _