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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 16.67
Human Site: Y317 Identified Species: 26.19
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 Y317 R I S T A T P Y M N G E T S T
Chimpanzee Pan troglodytes XP_001160550 1044 119347 P305 K P R A K P P P I P A K K P S
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 L315 S S N L P L P L P P K K T R I
Dog Lupus familis XP_546764 1044 119674 P305 K P R T K P P P I P M K K P S
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 Y317 R I S T A T P Y M N G E T S T
Rat Rattus norvegicus Q9Z1L0 1070 122589 L315 S S S L P L P L P P K K T R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 Y317 R I S T A T P Y M N G E A S A
Chicken Gallus gallus NP_001004410 1068 124270 Y317 R I S T A T P Y M N G E A T A
Frog Xenopus laevis Q6AZN6 886 101139 E220 N F M Y L M V E F P C V K C D
Zebra Danio Brachydanio rerio XP_690235 1069 124426 Y317 R I S T A T P Y M N G E A S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 K312 S T L T L R K K G K H V S A W
Nematode Worm Caenorhab. elegans Q94125 1182 136855 R412 D M V M T D F R P T A S L K Q
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 A301 L A Q K E E Q A P P L P S K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 F148 G K E A D G S F P T S T P G K
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 P209 F V L N L E F P M L E L P V V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 6.6 13.3 13.3 N.A. 100 20 N.A. 86.6 80 0 93.3 N.A. N.A. 6.6 0 0
P-Site Similarity: 100 33.3 26.6 40 N.A. 100 26.6 N.A. 86.6 86.6 0 93.3 N.A. N.A. 20 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 14 34 0 0 7 0 0 14 0 20 7 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 0 % C
% Asp: 7 0 0 0 7 7 0 0 0 0 0 0 0 0 7 % D
% Glu: 0 0 7 0 7 14 0 7 0 0 7 34 0 0 0 % E
% Phe: 7 7 0 0 0 0 14 7 7 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 7 0 0 7 0 34 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 34 0 0 0 0 0 0 14 0 0 0 0 0 7 % I
% Lys: 14 7 0 7 14 0 7 7 0 7 14 27 20 14 7 % K
% Leu: 7 0 14 14 20 14 0 14 0 7 7 7 7 0 0 % L
% Met: 0 7 7 7 0 7 0 0 40 0 7 0 0 0 0 % M
% Asn: 7 0 7 7 0 0 0 0 0 34 0 0 0 0 0 % N
% Pro: 0 14 0 0 14 14 60 20 34 40 0 7 14 14 0 % P
% Gln: 0 0 7 0 0 0 7 0 0 0 0 0 0 0 7 % Q
% Arg: 34 0 14 0 0 7 0 7 0 0 0 0 0 14 0 % R
% Ser: 20 14 40 0 0 0 7 0 0 0 7 7 14 27 14 % S
% Thr: 0 7 0 47 7 34 0 0 0 14 0 7 27 7 20 % T
% Val: 0 7 7 0 0 0 7 0 0 0 0 14 0 7 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 7 0 0 0 34 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _