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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
18.18
Human Site:
Y355
Identified Species:
28.57
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
V343
D
E
R
M
K
L
V
V
Q
A
G
L
F
H
G
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
V353
E
E
T
V
K
V
H
V
R
A
G
L
F
H
G
Dog
Lupus familis
XP_546764
1044
119674
V343
D
E
R
M
K
L
V
V
Q
A
G
L
F
H
G
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
V353
E
E
T
V
K
V
H
V
R
A
G
L
F
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Chicken
Gallus gallus
NP_001004410
1068
124270
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Frog
Xenopus laevis
Q6AZN6
886
101139
P258
E
I
V
R
V
P
D
P
Q
M
S
M
E
N
L
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y355
I
R
D
I
D
K
I
Y
V
R
T
G
I
Y
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
A350
T
V
E
I
G
L
Q
A
G
L
F
H
G
G
K
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R450
A
D
V
D
M
Y
V
R
I
E
F
S
V
Y
V
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
R339
V
I
E
K
S
G
V
R
L
K
A
G
V
F
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
D186
I
Q
S
I
D
W
L
D
R
L
M
L
K
S
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
R247
T
D
L
R
E
P
N
R
N
D
P
Q
I
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
0
0
0
N.A.
100
0
N.A.
100
100
0
100
N.A.
N.A.
6.6
6.6
13.3
P-Site Similarity:
100
20
13.3
20
N.A.
100
13.3
N.A.
100
100
6.6
100
N.A.
N.A.
13.3
26.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
7
0
27
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
14
34
7
40
0
7
7
0
7
0
0
0
0
0
% D
% Glu:
20
27
14
0
7
0
0
0
0
7
0
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
14
0
27
7
0
% F
% Gly:
0
0
0
0
7
7
0
0
7
0
27
40
7
7
27
% G
% His:
0
0
0
0
0
0
14
0
0
0
0
7
0
27
40
% H
% Ile:
40
14
0
47
0
0
34
0
7
0
0
0
40
0
7
% I
% Lys:
0
0
0
7
27
34
0
0
0
7
0
0
7
7
7
% K
% Leu:
0
0
7
0
0
20
7
0
7
14
0
34
0
0
14
% L
% Met:
0
0
0
14
7
0
0
0
0
7
7
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
7
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
14
0
7
0
0
7
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
7
0
20
0
0
7
0
0
0
% Q
% Arg:
0
34
14
14
0
0
0
20
20
34
0
0
0
0
0
% R
% Ser:
0
0
7
0
7
0
0
0
0
0
7
7
0
7
0
% S
% Thr:
14
0
14
0
0
0
0
0
0
0
34
0
0
0
0
% T
% Val:
7
7
14
14
7
14
27
27
34
0
0
0
14
0
7
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
34
0
0
0
0
0
40
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _