Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 16.06
Human Site: Y508 Identified Species: 25.24
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 Y508 S R E A G F S Y S H A G L S N
Chimpanzee Pan troglodytes XP_001160550 1044 119347 G495 L E K I L E L G R H S E C V H
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 I518 I I E K A A E I A S S D S A N
Dog Lupus familis XP_546764 1044 119674 G495 L D K I L E L G R H G E H G R
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 Y508 S R E A G F S Y S H T G L S N
Rat Rattus norvegicus Q9Z1L0 1070 122589 E517 K I I E K A A E I A S G D S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 Y508 S R E L G F N Y S H A G L S N
Chicken Gallus gallus NP_001004410 1068 124270 Y508 S R E L G F N Y S Y A G L S N
Frog Xenopus laevis Q6AZN6 886 101139 L393 Q A D D E D L L M Y L L Q L V
Zebra Danio Brachydanio rerio XP_690235 1069 124426 Y508 S R E M G Y N Y C Q S G Q S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 E517 K L R E S S T E R S I Q E E P
Nematode Worm Caenorhab. elegans Q94125 1182 136855 W592 L V K H R S T W T E T L N I M
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 I486 M W P A S E D I D L N P L G H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 L321 L M S E K R A L T K F L R C V
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 F382 L E L L G S T F K N L S V R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 6.6 13.3 6.6 N.A. 93.3 13.3 N.A. 86.6 80 0 46.6 N.A. N.A. 0 0 13.3
P-Site Similarity: 100 26.6 33.3 13.3 N.A. 93.3 26.6 N.A. 93.3 93.3 13.3 73.3 N.A. N.A. 6.6 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 20 7 14 14 0 7 7 20 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % C
% Asp: 0 7 7 7 0 7 7 0 7 0 0 7 7 0 0 % D
% Glu: 0 14 40 20 7 20 7 14 0 7 0 14 7 7 0 % E
% Phe: 0 0 0 0 0 27 0 7 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 0 40 0 0 14 0 0 7 40 0 14 0 % G
% His: 0 0 0 7 0 0 0 0 0 34 0 0 7 0 14 % H
% Ile: 7 14 7 14 0 0 0 14 7 0 7 0 0 7 0 % I
% Lys: 14 0 20 7 14 0 0 0 7 7 0 0 0 0 0 % K
% Leu: 34 7 7 20 14 0 20 14 0 7 14 20 34 7 0 % L
% Met: 7 7 0 7 0 0 0 0 7 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 20 0 0 7 7 0 7 0 34 % N
% Pro: 0 0 7 0 0 0 0 0 0 0 0 7 0 0 7 % P
% Gln: 7 0 0 0 0 0 0 0 0 7 0 7 14 0 0 % Q
% Arg: 0 34 7 0 7 7 0 0 20 0 0 0 7 7 7 % R
% Ser: 34 0 7 0 14 20 14 0 27 14 27 7 7 40 14 % S
% Thr: 0 0 0 0 0 0 20 0 14 0 14 0 0 0 0 % T
% Val: 0 7 0 0 0 0 0 0 0 0 0 0 7 7 14 % V
% Trp: 0 7 0 0 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 34 0 14 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _