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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CA All Species: 41.21
Human Site: Y641 Identified Species: 64.76
UniProt: P42336 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42336 NP_006209.2 1068 124284 Y641 Q L V Q V L K Y E Q Y L D N L
Chimpanzee Pan troglodytes XP_001160550 1044 119347 Y621 Q L V Q V L K Y E S Y L D C E
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 Y648 Q L V Q V L K Y E P F L D C A
Dog Lupus familis XP_546764 1044 119674 Y621 Q L V Q V L K Y E S Y L D C E
Cat Felis silvestris
Mouse Mus musculus P42337 1068 124436 Y641 Q L V Q V L K Y E Q Y L D N L
Rat Rattus norvegicus Q9Z1L0 1070 122589 Y648 Q L V Q V L K Y E P F L D C A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505664 1068 124323 Y641 Q L V Q V L K Y E Q Y L D N L
Chicken Gallus gallus NP_001004410 1068 124270 Y641 Q L V Q V L K Y E Q Y L D N Q
Frog Xenopus laevis Q6AZN6 886 101139 T512 T Q L R D P K T H E M Y L N V
Zebra Danio Brachydanio rerio XP_690235 1069 124426 Y641 Q L V Q V L K Y E Q Y L D N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 H648 Q L V Q A L K H E N Y L S C D
Nematode Worm Caenorhab. elegans Q94125 1182 136855 Y728 P L I Q A L K Y E P R A Q S E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 Y626 Q L V Q A L K Y E T H L D C A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 Y440 H V Y A K R F Y S T Y E L L E
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 Y501 L G S F F Y W Y L K S E S E D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.5 41.5 41 N.A. 98.5 41.3 N.A. 97.5 96.2 21.3 91.6 N.A. N.A. 40.1 26.7 35.3
Protein Similarity: 100 57.9 59.8 58.6 N.A. 99.2 59.5 N.A. 98.9 98.5 40 96 N.A. N.A. 59.2 46.7 55.4
P-Site Identity: 100 80 73.3 80 N.A. 100 73.3 N.A. 100 93.3 13.3 93.3 N.A. N.A. 60 40 66.6
P-Site Similarity: 100 80 80 80 N.A. 100 80 N.A. 100 93.3 40 93.3 N.A. N.A. 66.6 53.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 22.3 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 20 0 0 0 0 0 0 7 0 0 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 40 0 % C
% Asp: 0 0 0 0 7 0 0 0 0 0 0 0 67 0 14 % D
% Glu: 0 0 0 0 0 0 0 0 80 7 0 14 0 7 27 % E
% Phe: 0 0 0 7 7 0 7 0 0 0 14 0 0 0 0 % F
% Gly: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 7 0 0 0 0 0 0 7 7 0 7 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 7 0 87 0 0 7 0 0 0 0 0 % K
% Leu: 7 80 7 0 0 80 0 0 7 0 0 74 14 7 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 0 40 0 % N
% Pro: 7 0 0 0 0 7 0 0 0 20 0 0 0 0 7 % P
% Gln: 74 7 0 80 0 0 0 0 0 34 0 0 7 0 7 % Q
% Arg: 0 0 0 7 0 7 0 0 0 0 7 0 0 0 0 % R
% Ser: 0 0 7 0 0 0 0 0 7 14 7 0 14 7 0 % S
% Thr: 7 0 0 0 0 0 0 7 0 14 0 0 0 0 0 % T
% Val: 0 7 74 0 60 0 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 7 0 87 0 0 60 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _