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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
41.21
Human Site:
Y641
Identified Species:
64.76
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
Y621
Q
L
V
Q
V
L
K
Y
E
S
Y
L
D
C
E
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
Y648
Q
L
V
Q
V
L
K
Y
E
P
F
L
D
C
A
Dog
Lupus familis
XP_546764
1044
119674
Y621
Q
L
V
Q
V
L
K
Y
E
S
Y
L
D
C
E
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y648
Q
L
V
Q
V
L
K
Y
E
P
F
L
D
C
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
L
Chicken
Gallus gallus
NP_001004410
1068
124270
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
Q
Frog
Xenopus laevis
Q6AZN6
886
101139
T512
T
Q
L
R
D
P
K
T
H
E
M
Y
L
N
V
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y641
Q
L
V
Q
V
L
K
Y
E
Q
Y
L
D
N
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
H648
Q
L
V
Q
A
L
K
H
E
N
Y
L
S
C
D
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Y728
P
L
I
Q
A
L
K
Y
E
P
R
A
Q
S
E
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
Y626
Q
L
V
Q
A
L
K
Y
E
T
H
L
D
C
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Y440
H
V
Y
A
K
R
F
Y
S
T
Y
E
L
L
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
Y501
L
G
S
F
F
Y
W
Y
L
K
S
E
S
E
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
80
73.3
80
N.A.
100
73.3
N.A.
100
93.3
13.3
93.3
N.A.
N.A.
60
40
66.6
P-Site Similarity:
100
80
80
80
N.A.
100
80
N.A.
100
93.3
40
93.3
N.A.
N.A.
66.6
53.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
20
0
0
0
0
0
0
7
0
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
40
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
0
0
67
0
14
% D
% Glu:
0
0
0
0
0
0
0
0
80
7
0
14
0
7
27
% E
% Phe:
0
0
0
7
7
0
7
0
0
0
14
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
7
7
0
7
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
7
0
87
0
0
7
0
0
0
0
0
% K
% Leu:
7
80
7
0
0
80
0
0
7
0
0
74
14
7
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
40
0
% N
% Pro:
7
0
0
0
0
7
0
0
0
20
0
0
0
0
7
% P
% Gln:
74
7
0
80
0
0
0
0
0
34
0
0
7
0
7
% Q
% Arg:
0
0
0
7
0
7
0
0
0
0
7
0
0
0
0
% R
% Ser:
0
0
7
0
0
0
0
0
7
14
7
0
14
7
0
% S
% Thr:
7
0
0
0
0
0
0
7
0
14
0
0
0
0
0
% T
% Val:
0
7
74
0
60
0
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
7
0
87
0
0
60
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _