KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
27.88
Human Site:
Y644
Identified Species:
43.81
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
Y624
Q
V
L
K
Y
E
S
Y
L
D
C
E
L
T
K
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
F651
Q
V
L
K
Y
E
P
F
L
D
C
A
L
S
R
Dog
Lupus familis
XP_546764
1044
119674
Y624
Q
V
L
K
Y
E
S
Y
L
D
C
E
L
T
K
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
F651
Q
V
L
K
Y
E
P
F
L
D
C
A
L
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
L
L
V
R
Chicken
Gallus gallus
NP_001004410
1068
124270
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
Q
L
V
R
Frog
Xenopus laevis
Q6AZN6
886
101139
M515
R
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y644
Q
V
L
K
Y
E
Q
Y
L
D
N
P
L
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y651
Q
A
L
K
H
E
N
Y
L
S
C
D
L
T
E
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R731
Q
A
L
K
Y
E
P
R
A
Q
S
E
V
G
M
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
H629
Q
A
L
K
Y
E
T
H
L
D
C
A
I
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Y443
A
K
R
F
Y
S
T
Y
E
L
L
E
E
N
I
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S504
F
F
Y
W
Y
L
K
S
E
S
E
D
K
P
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
66.6
66.6
66.6
N.A.
100
66.6
N.A.
100
93.3
20
93.3
N.A.
N.A.
46.6
33.3
46.6
P-Site Similarity:
100
73.3
73.3
73.3
N.A.
100
73.3
N.A.
100
93.3
46.6
93.3
N.A.
N.A.
53.3
46.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
20
0
0
0
0
0
0
7
0
0
20
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
40
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
67
0
14
0
0
0
% D
% Glu:
0
0
0
0
0
80
7
0
14
0
7
27
7
0
7
% E
% Phe:
7
7
0
7
0
0
0
14
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% G
% His:
0
0
0
0
7
7
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% I
% Lys:
0
7
0
87
0
0
7
0
0
0
0
0
7
0
20
% K
% Leu:
0
0
80
0
0
7
0
0
74
14
7
20
67
0
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
7
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
40
0
0
7
0
% N
% Pro:
0
0
7
0
0
0
20
0
0
0
0
7
0
7
0
% P
% Gln:
80
0
0
0
0
0
34
0
0
7
0
7
0
0
0
% Q
% Arg:
7
0
7
0
0
0
0
7
0
0
0
0
0
7
54
% R
% Ser:
0
0
0
0
0
7
14
7
0
14
7
0
0
14
0
% S
% Thr:
0
0
0
0
7
0
14
0
0
0
0
0
0
20
0
% T
% Val:
0
60
0
0
0
0
0
0
0
0
0
7
7
34
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
87
0
0
60
7
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _