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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CA
All Species:
20
Human Site:
Y890
Identified Species:
31.43
UniProt:
P42336
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42336
NP_006209.2
1068
124284
Y890
D
K
N
K
G
E
I
Y
D
A
A
I
D
L
F
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
L868
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
L894
E
Y
N
S
G
D
D
L
D
R
A
I
E
E
F
Dog
Lupus familis
XP_546764
1044
119674
L868
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
Cat
Felis silvestris
Mouse
Mus musculus
P42337
1068
124436
Y890
D
K
N
K
G
E
I
Y
D
A
A
I
D
L
F
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
L894
E
Y
N
S
G
D
D
L
D
R
A
I
E
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
Y890
D
K
N
K
G
E
M
Y
D
A
A
I
D
L
F
Chicken
Gallus gallus
NP_001004410
1068
124270
Y890
D
K
N
K
G
E
M
Y
D
A
A
I
D
L
F
Frog
Xenopus laevis
Q6AZN6
886
101139
D722
G
I
S
A
E
V
M
D
T
Y
V
K
S
C
A
Zebra Danio
Brachydanio rerio
XP_690235
1069
124426
Y890
D
K
N
K
G
E
M
Y
D
M
A
I
D
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
L892
H
N
H
T
E
A
A
L
N
R
A
I
E
E
F
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Y1006
N
T
Q
A
M
K
K
Y
F
E
S
V
D
R
F
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
L875
H
S
P
T
E
E
M
L
N
K
A
I
E
D
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L650
F
G
I
T
A
T
C
L
D
T
F
I
K
S
C
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D711
G
V
Q
G
W
V
L
D
N
F
V
K
S
C
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.5
41.5
41
N.A.
98.5
41.3
N.A.
97.5
96.2
21.3
91.6
N.A.
N.A.
40.1
26.7
35.3
Protein Similarity:
100
57.9
59.8
58.6
N.A.
99.2
59.5
N.A.
98.9
98.5
40
96
N.A.
N.A.
59.2
46.7
55.4
P-Site Identity:
100
53.3
40
53.3
N.A.
100
40
N.A.
93.3
93.3
0
86.6
N.A.
N.A.
20
20
26.6
P-Site Similarity:
100
60
60
60
N.A.
100
60
N.A.
100
100
13.3
93.3
N.A.
N.A.
40
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.1
41.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
7
7
20
0
0
27
74
0
0
0
14
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
14
7
% C
% Asp:
34
0
0
0
0
14
14
14
67
0
0
0
40
7
0
% D
% Glu:
14
0
0
0
20
54
0
0
0
7
0
0
40
34
0
% E
% Phe:
7
0
0
0
0
0
0
0
7
7
7
0
0
0
80
% F
% Gly:
14
7
0
7
60
0
0
0
0
0
0
0
0
0
0
% G
% His:
14
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
0
0
14
0
0
0
0
80
0
0
0
% I
% Lys:
0
47
0
34
0
7
7
0
0
7
0
14
7
0
0
% K
% Leu:
0
0
0
0
0
0
7
47
0
0
0
0
0
34
0
% L
% Met:
0
0
0
0
7
0
34
0
0
7
0
0
0
0
0
% M
% Asn:
7
7
60
0
0
0
0
0
20
0
0
0
0
0
0
% N
% Pro:
0
0
7
14
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
14
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
34
0
0
0
7
0
% R
% Ser:
14
7
7
14
0
0
0
0
0
0
7
0
14
7
0
% S
% Thr:
0
7
0
20
0
7
0
0
7
7
0
0
0
0
0
% T
% Val:
0
7
0
0
0
14
0
0
0
0
14
7
0
0
0
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
14
0
0
0
0
0
40
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _