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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
20.3
Human Site:
S124
Identified Species:
31.9
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
S124
D
P
G
E
K
L
D
S
K
I
G
V
L
I
G
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
L119
L
I
N
S
Q
I
S
L
L
I
G
K
G
L
H
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S124
D
P
G
E
K
L
D
S
K
I
G
V
L
I
G
Dog
Lupus familis
XP_534280
1070
122787
S124
D
P
G
E
K
L
D
S
K
I
G
V
L
I
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
I120
A
E
K
L
D
S
K
I
G
V
R
I
G
K
G
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S124
D
P
A
E
K
L
D
S
K
I
G
V
L
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S256
D
P
G
E
K
L
D
S
K
I
G
V
L
I
G
Chicken
Gallus gallus
NP_001026482
1066
122000
I120
G
E
K
L
D
S
K
I
G
V
L
I
G
K
G
Frog
Xenopus laevis
Q6AZN6
886
101139
E40
K
S
Y
K
A
V
L
E
D
P
M
L
K
F
S
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
R119
M
S
W
G
Q
W
L
R
S
S
Y
S
P
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
V120
N
L
D
S
R
I
G
V
L
I
G
K
G
L
H
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S184
N
R
D
K
E
L
M
S
D
I
S
H
C
L
G
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
H127
L
C
I
G
K
S
L
H
E
Y
D
M
M
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
K29
I
K
S
L
E
G
H
K
P
L
L
K
P
S
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
13.3
100
100
N.A.
6.6
93.3
N.A.
100
6.6
0
0
N.A.
N.A.
13.3
26.6
6.6
P-Site Similarity:
100
33.3
100
100
N.A.
20
93.3
N.A.
100
20
20
6.6
N.A.
N.A.
40
53.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
34
0
14
0
14
0
34
0
14
0
7
0
0
0
0
% D
% Glu:
0
14
0
34
14
0
0
7
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
7
0
27
14
0
7
7
0
14
0
47
0
27
0
54
% G
% His:
0
0
0
0
0
0
7
7
0
0
0
7
0
0
14
% H
% Ile:
7
7
7
0
0
14
0
14
0
54
0
14
0
34
0
% I
% Lys:
7
7
14
14
40
0
14
7
34
0
0
20
7
20
0
% K
% Leu:
14
7
0
20
0
40
20
7
14
7
14
7
34
20
7
% L
% Met:
7
0
0
0
0
0
7
0
0
0
7
7
7
0
0
% M
% Asn:
14
0
7
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
34
0
0
0
0
0
0
7
7
0
0
14
0
0
% P
% Gln:
0
0
0
0
14
0
0
0
0
0
0
0
0
7
7
% Q
% Arg:
0
7
0
0
7
0
0
7
0
0
7
0
0
0
0
% R
% Ser:
0
14
7
14
0
20
7
40
7
7
7
7
0
7
7
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
7
0
7
0
14
0
34
0
0
0
% V
% Trp:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
7
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _