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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CB All Species: 27.88
Human Site: S309 Identified Species: 43.81
UniProt: P42338 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42338 NP_006210.1 1070 122762 S309 A A I N R N S S N L P L P L P
Chimpanzee Pan troglodytes XP_001160550 1044 119347 R300 A P Q V Q K P R A K P P P I P
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 S309 A A I N R N S S N L P L P L P
Dog Lupus familis XP_534280 1070 122787 S309 A A I N R N A S N L P L P L P
Cat Felis silvestris
Mouse Mus musculus Q8BTI9 1064 121735 S303 A A I N R N S S N L P L P L P
Rat Rattus norvegicus Q9Z1L0 1070 122589 S309 A A I N R N S S S L P L P L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 S441 A A I N R N S S N L P L P L P
Chicken Gallus gallus NP_001026482 1066 122000 S304 V A I N R K S S N L P L P L P
Frog Xenopus laevis Q6AZN6 886 101139 S207 E I E M I N E S E K R S S N F
Zebra Danio Brachydanio rerio XP_001923257 1022 117051 R286 W K V H S L F R I N L V K A N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 R301 A D T L Q R T R P S F S T L T
Nematode Worm Caenorhab. elegans Q94125 1182 136855 N403 S T P K Q S K N S D M V M T D
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 P302 A Q K E E Q A P P L P S K A G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 K135 Q M K S G K Q K L R L W Q G K
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 T196 R K Q R E N R T W P Q G T F V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.5 99.6 97.2 N.A. 95.2 95.8 N.A. 81.1 86.6 23.6 65.5 N.A. N.A. 46.6 26.4 42.9
Protein Similarity: 100 72.9 99.9 98.8 N.A. 97 97.8 N.A. 85.3 93.6 41.3 79.7 N.A. N.A. 65.6 47.8 63.6
P-Site Identity: 100 26.6 100 93.3 N.A. 100 93.3 N.A. 100 86.6 13.3 0 N.A. N.A. 13.3 0 20
P-Site Similarity: 100 40 100 100 N.A. 100 100 N.A. 100 86.6 13.3 20 N.A. N.A. 26.6 40 26.6
Percent
Protein Identity: N.A. N.A. N.A. 22.7 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. 38.6 41.9 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 60 47 0 0 0 0 14 0 7 0 0 0 0 14 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 7 0 0 0 0 7 % D
% Glu: 7 0 7 7 14 0 7 0 7 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 7 0 0 7 7 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 7 0 7 7 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 47 0 7 0 0 0 7 0 0 0 0 7 0 % I
% Lys: 0 14 14 7 0 20 7 7 0 14 0 0 14 0 7 % K
% Leu: 0 0 0 7 0 7 0 0 7 54 14 47 0 54 0 % L
% Met: 0 7 0 7 0 0 0 0 0 0 7 0 7 0 0 % M
% Asn: 0 0 0 47 0 54 0 7 40 7 0 0 0 7 7 % N
% Pro: 0 7 7 0 0 0 7 7 14 7 60 7 54 0 54 % P
% Gln: 7 7 14 0 20 7 7 0 0 0 7 0 7 0 0 % Q
% Arg: 7 0 0 7 47 7 7 20 0 7 7 0 0 0 0 % R
% Ser: 7 0 0 7 7 7 40 54 14 7 0 20 7 0 0 % S
% Thr: 0 7 7 0 0 0 7 7 0 0 0 0 14 7 7 % T
% Val: 7 0 7 7 0 0 0 0 0 0 0 14 0 0 7 % V
% Trp: 7 0 0 0 0 0 0 0 7 0 0 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _