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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CB
All Species:
18.18
Human Site:
S521
Identified Species:
28.57
UniProt:
P42338
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42338
NP_006210.1
1070
122762
S521
K
A
A
E
I
A
S
S
D
S
A
N
V
S
S
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
V501
L
G
R
H
S
E
C
V
H
V
T
E
E
E
Q
Rhesus Macaque
Macaca mulatta
XP_001113960
1070
122801
S521
K
A
A
E
I
A
S
S
D
S
A
N
V
S
S
Dog
Lupus familis
XP_534280
1070
122787
S521
K
A
A
E
I
A
S
S
D
S
A
N
V
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTI9
1064
121735
G515
K
A
A
E
L
A
S
G
D
S
A
N
V
S
S
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
G521
K
A
A
E
I
A
S
G
D
S
A
N
V
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S653
K
A
A
E
I
A
S
S
D
S
G
N
M
A
S
Chicken
Gallus gallus
NP_001026482
1066
122000
S516
K
A
A
E
I
A
R
S
S
D
N
A
A
M
A
Frog
Xenopus laevis
Q6AZN6
886
101139
L397
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
L
K
Zebra Danio
Brachydanio rerio
XP_001923257
1022
117051
M477
I
A
G
A
S
D
S
M
S
M
G
R
G
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
E513
E
Y
A
R
K
L
R
E
S
S
T
E
R
S
I
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
D602
T
L
N
I
M
G
D
D
Y
E
S
C
I
R
D
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S519
Q
Y
R
Q
G
S
V
S
Y
P
T
F
D
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L325
K
R
A
L
T
K
F
L
R
C
V
E
W
S
D
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S386
G
S
T
F
K
N
L
S
V
R
S
Y
A
V
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56.5
99.6
97.2
N.A.
95.2
95.8
N.A.
81.1
86.6
23.6
65.5
N.A.
N.A.
46.6
26.4
42.9
Protein Similarity:
100
72.9
99.9
98.8
N.A.
97
97.8
N.A.
85.3
93.6
41.3
79.7
N.A.
N.A.
65.6
47.8
63.6
P-Site Identity:
100
0
100
100
N.A.
86.6
93.3
N.A.
80
46.6
0
13.3
N.A.
N.A.
20
0
6.6
P-Site Similarity:
100
0
100
100
N.A.
93.3
93.3
N.A.
93.3
53.3
13.3
13.3
N.A.
N.A.
26.6
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
41.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
54
60
7
0
47
0
0
0
0
34
7
20
7
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
7
0
7
0
0
0
% C
% Asp:
0
7
0
0
0
7
7
7
40
7
0
0
7
0
14
% D
% Glu:
14
0
0
47
0
7
0
7
0
7
0
20
7
7
0
% E
% Phe:
0
0
0
7
0
0
7
0
0
0
0
7
0
0
0
% F
% Gly:
7
7
7
0
7
7
0
14
0
0
14
0
7
7
0
% G
% His:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
40
0
0
0
0
0
0
0
7
0
7
% I
% Lys:
54
0
0
0
14
7
0
0
0
0
0
0
0
7
14
% K
% Leu:
7
7
7
14
7
7
14
14
0
7
0
0
0
7
0
% L
% Met:
0
0
0
0
14
0
0
7
0
7
0
0
7
7
0
% M
% Asn:
0
0
7
0
0
7
0
0
0
0
7
40
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% P
% Gln:
7
0
0
7
0
0
0
0
7
0
0
7
0
0
7
% Q
% Arg:
0
7
14
7
0
0
14
0
7
7
0
7
7
7
0
% R
% Ser:
0
7
0
0
14
7
47
47
20
47
14
0
0
47
40
% S
% Thr:
7
0
7
0
7
0
0
0
0
0
20
0
0
0
0
% T
% Val:
0
0
0
0
0
0
7
7
7
7
14
0
34
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
14
0
0
0
7
0
0
14
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _