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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CB All Species: 27.88
Human Site: S890 Identified Species: 43.81
UniProt: P42338 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42338 NP_006210.1 1070 122762 S890 N W L K E Y N S G D D L D R A
Chimpanzee Pan troglodytes XP_001160550 1044 119347 P864 N W L K S K N P G E A L D R A
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 S890 N W L K E Y N S G D D L D R A
Dog Lupus familis XP_534280 1070 122787 S890 N W L K E Y N S G D D L D R A
Cat Felis silvestris
Mouse Mus musculus Q8BTI9 1064 121735 S884 N W L K E Y N S G D D L D R A
Rat Rattus norvegicus Q9Z1L0 1070 122589 S890 N W L K E Y N S G D D L D R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 S989 L I E V V S T S E T I A D I Q
Chicken Gallus gallus NP_001026482 1066 122000 L886 N W L K E Y N L G D D L D R A
Frog Xenopus laevis Q6AZN6 886 101139 P713 Y S P S E K G P Y G I S A E V
Zebra Danio Brachydanio rerio XP_001923257 1022 117051 S844 N W L K D K N S G D A L D K A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 T888 W L K D H N H T E A A L N R A
Nematode Worm Caenorhab. elegans Q94125 1182 136855 A1002 K K I D N T Q A M K K Y F E S
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 T871 W L K K H S P T E E M L N K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 A641 K F H P D E H A P F G I T A T
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 T702 H Y P D E N A T L G V Q G W V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.5 99.6 97.2 N.A. 95.2 95.8 N.A. 81.1 86.6 23.6 65.5 N.A. N.A. 46.6 26.4 42.9
Protein Similarity: 100 72.9 99.9 98.8 N.A. 97 97.8 N.A. 85.3 93.6 41.3 79.7 N.A. N.A. 65.6 47.8 63.6
P-Site Identity: 100 66.6 100 100 N.A. 100 100 N.A. 13.3 93.3 6.6 73.3 N.A. N.A. 20 0 20
P-Site Similarity: 100 73.3 100 100 N.A. 100 100 N.A. 13.3 93.3 6.6 86.6 N.A. N.A. 40 20 46.6
Percent
Protein Identity: N.A. N.A. N.A. 22.7 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. 38.6 41.9 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 14 0 7 20 7 7 7 67 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 20 14 0 0 0 0 47 40 0 60 0 0 % D
% Glu: 0 0 7 0 54 7 0 0 20 14 0 0 0 14 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 7 0 54 14 7 0 7 0 0 % G
% His: 7 0 7 0 14 0 14 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 7 0 0 0 0 0 0 0 14 7 0 7 0 % I
% Lys: 14 7 14 60 0 20 0 0 0 7 7 0 0 14 0 % K
% Leu: 7 14 54 0 0 0 0 7 7 0 0 67 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 7 0 0 0 0 % M
% Asn: 54 0 0 0 7 14 54 0 0 0 0 0 14 0 0 % N
% Pro: 0 0 14 7 0 0 7 14 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 7 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 54 0 % R
% Ser: 0 7 0 7 7 14 0 47 0 0 0 7 0 0 7 % S
% Thr: 0 0 0 0 0 7 7 20 0 7 0 0 7 0 7 % T
% Val: 0 0 0 7 7 0 0 0 0 0 7 0 0 0 14 % V
% Trp: 14 54 0 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 7 7 0 0 0 40 0 0 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _