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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CB All Species: 35.76
Human Site: T478 Identified Species: 56.19
UniProt: P42338 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42338 NP_006210.1 1070 122762 T478 E M L N P M G T V Q T N P Y T
Chimpanzee Pan troglodytes XP_001160550 1044 119347 T458 E L L N P T G T V R S N P N T
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 T478 E M L N P M G T V Q T N P Y T
Dog Lupus familis XP_534280 1070 122787 T478 E M L N P M G T V Q T N P Y T
Cat Felis silvestris
Mouse Mus musculus Q8BTI9 1064 121735 T472 E M L N P M G T V Q T N P Y A
Rat Rattus norvegicus Q9Z1L0 1070 122589 T478 E M L N P M G T V Q T N P Y A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 T610 E M L N P M G T V Q T N P Y T
Chicken Gallus gallus NP_001026482 1066 122000 T473 E M L N P M G T V Q T N P Y T
Frog Xenopus laevis Q6AZN6 886 101139 K354 Q A L E L L G K W K P M D V E
Zebra Danio Brachydanio rerio XP_001923257 1022 117051 N434 P I G T I Q T N P Y T E N A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 T470 D L L H P L G T V V S N P H I
Nematode Worm Caenorhab. elegans Q94125 1182 136855 T559 E N G A R I G T N A A V T I E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 K476 Q L R S G P H K L F M W P A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 I282 R D L K P S N I E R K S I Q R
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 K343 N N K K A L T K L L Q S T N L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.5 99.6 97.2 N.A. 95.2 95.8 N.A. 81.1 86.6 23.6 65.5 N.A. N.A. 46.6 26.4 42.9
Protein Similarity: 100 72.9 99.9 98.8 N.A. 97 97.8 N.A. 85.3 93.6 41.3 79.7 N.A. N.A. 65.6 47.8 63.6
P-Site Identity: 100 66.6 100 100 N.A. 93.3 93.3 N.A. 100 100 13.3 13.3 N.A. N.A. 46.6 20 6.6
P-Site Similarity: 100 86.6 100 100 N.A. 93.3 93.3 N.A. 100 100 33.3 20 N.A. N.A. 86.6 26.6 40
Percent
Protein Identity: N.A. N.A. N.A. 22.7 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. 38.6 41.9 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 7 0 0 0 0 7 7 0 0 14 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 0 0 0 0 0 0 0 0 7 0 0 % D
% Glu: 60 0 0 7 0 0 0 0 7 0 0 7 0 0 14 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 14 0 7 0 74 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 0 7 0 0 0 0 0 0 7 0 % H
% Ile: 0 7 0 0 7 7 0 7 0 0 0 0 7 7 7 % I
% Lys: 0 0 7 14 0 0 0 20 0 7 7 0 0 0 0 % K
% Leu: 0 20 74 0 7 20 0 0 14 7 0 0 0 0 7 % L
% Met: 0 47 0 0 0 47 0 0 0 0 7 7 0 0 0 % M
% Asn: 7 14 0 54 0 0 7 7 7 0 0 60 7 14 0 % N
% Pro: 7 0 0 0 67 7 0 0 7 0 7 0 67 0 0 % P
% Gln: 14 0 0 0 0 7 0 0 0 47 7 0 0 7 0 % Q
% Arg: 7 0 7 0 7 0 0 0 0 14 0 0 0 0 7 % R
% Ser: 0 0 0 7 0 7 0 0 0 0 14 14 0 0 7 % S
% Thr: 0 0 0 7 0 7 14 67 0 0 54 0 14 0 47 % T
% Val: 0 0 0 0 0 0 0 0 60 7 0 7 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 0 0 0 47 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _