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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CB All Species: 29.7
Human Site: Y246 Identified Species: 46.67
UniProt: P42338 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42338 NP_006210.1 1070 122762 Y246 D E V S P Y D Y V L Q V S G R
Chimpanzee Pan troglodytes XP_001160550 1044 119347 Y239 L V E Q P E D Y T L Q V N G R
Rhesus Macaque Macaca mulatta XP_001113960 1070 122801 Y246 D E V S P Y D Y V L Q V S G R
Dog Lupus familis XP_534280 1070 122787 Y246 D E V S P N D Y V L Q V S G R
Cat Felis silvestris
Mouse Mus musculus Q8BTI9 1064 121735 Y240 D E A S P C D Y V L Q V S G R
Rat Rattus norvegicus Q9Z1L0 1070 122589 Y246 E E A S P C D Y V L Q V S G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 Y378 D E V N P Y D Y V L Q V S G K
Chicken Gallus gallus NP_001026482 1066 122000 Y241 E E I D P A D Y V L Q V S G R
Frog Xenopus laevis Q6AZN6 886 101139 S154 P N I E A D G S E L T K T P G
Zebra Danio Brachydanio rerio XP_001923257 1022 117051 D233 H L T V V H F D I V K S M F E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 F238 S K G H P N D F T L K V C G Q
Nematode Worm Caenorhab. elegans Q94125 1182 136855 F319 D P A D E G W F L Q L A G R T
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 P247 D F L L G G H P L S K Y K Y P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 E82 G P P Y C W N E L I T L S S K
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 S143 T L K R G F E S L K F R Y D V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.5 99.6 97.2 N.A. 95.2 95.8 N.A. 81.1 86.6 23.6 65.5 N.A. N.A. 46.6 26.4 42.9
Protein Similarity: 100 72.9 99.9 98.8 N.A. 97 97.8 N.A. 85.3 93.6 41.3 79.7 N.A. N.A. 65.6 47.8 63.6
P-Site Identity: 100 53.3 100 93.3 N.A. 86.6 80 N.A. 86.6 73.3 6.6 0 N.A. N.A. 33.3 6.6 6.6
P-Site Similarity: 100 60 100 93.3 N.A. 86.6 86.6 N.A. 100 86.6 20 26.6 N.A. N.A. 60 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 22.7 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. 38.6 41.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 20 0 7 7 0 0 0 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 7 14 0 0 0 0 0 0 7 0 0 % C
% Asp: 47 0 0 14 0 7 60 7 0 0 0 0 0 7 0 % D
% Glu: 14 47 7 7 7 7 7 7 7 0 0 0 0 0 7 % E
% Phe: 0 7 0 0 0 7 7 14 0 0 7 0 0 7 0 % F
% Gly: 7 0 7 0 14 14 7 0 0 0 0 0 7 60 7 % G
% His: 7 0 0 7 0 7 7 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 14 0 0 0 0 0 7 7 0 0 0 0 0 % I
% Lys: 0 7 7 0 0 0 0 0 0 7 20 7 7 0 14 % K
% Leu: 7 14 7 7 0 0 0 0 27 67 7 7 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 7 0 7 0 14 7 0 0 0 0 0 7 0 0 % N
% Pro: 7 14 7 0 60 0 0 7 0 0 0 0 0 7 7 % P
% Gln: 0 0 0 7 0 0 0 0 0 7 54 0 0 0 7 % Q
% Arg: 0 0 0 7 0 0 0 0 0 0 0 7 0 7 47 % R
% Ser: 7 0 0 34 0 0 0 14 0 7 0 7 54 7 0 % S
% Thr: 7 0 7 0 0 0 0 0 14 0 14 0 7 0 7 % T
% Val: 0 7 27 7 7 0 0 0 47 7 0 60 0 0 7 % V
% Trp: 0 0 0 0 0 7 7 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 20 0 54 0 0 0 7 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _