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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EPS15 All Species: 14.24
Human Site: T743 Identified Species: 31.33
UniProt: P42566 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42566 NP_001153441.1 896 98656 T743 E D P F R S A T S S S V S N V
Chimpanzee Pan troglodytes XP_001139393 896 98643 T743 E E P F R S A T S S S V S N V
Rhesus Macaque Macaca mulatta XP_001113811 1015 110551 L865 S G P F T S S L G G A G F S D
Dog Lupus familis XP_532580 889 97932 T733 E D P F N S A T L S S V N N V
Cat Felis silvestris
Mouse Mus musculus P42567 897 98453 I745 E D A F N P T I S S S T S S V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026454 920 100691 T769 E D P F S S S T S G S V K N V
Frog Xenopus laevis O42287 1270 143652 S862 D T W A A Q P S L T V P S A G
Zebra Danio Brachydanio rerio XP_002663145 1039 114340 V835 D P F G G S D V V A R D G P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122937 1043 116535 R782 D D N Q R F L R Y S F C L F S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192039 1179 125310 S909 F A S K A T K S D D P F A G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P34216 1381 150765 P1144 F E D T R E I P S A T V K T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 43.2 91.5 N.A. 89.3 N.A. N.A. N.A. 74.6 21 50.5 N.A. N.A. 30.1 N.A. 29.6
Protein Similarity: 100 99.7 59.5 94.5 N.A. 93.4 N.A. N.A. N.A. 84.1 34.9 64.4 N.A. N.A. 48.2 N.A. 44.3
P-Site Identity: 100 93.3 20 80 N.A. 53.3 N.A. N.A. N.A. 73.3 6.6 6.6 N.A. N.A. 20 N.A. 0
P-Site Similarity: 100 100 40 86.6 N.A. 60 N.A. N.A. N.A. 80 26.6 20 N.A. N.A. 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 10 19 0 28 0 0 19 10 0 10 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 28 46 10 0 0 0 10 0 10 10 0 10 0 0 10 % D
% Glu: 46 19 0 0 0 10 0 0 0 0 0 0 0 0 0 % E
% Phe: 19 0 10 55 0 10 0 0 0 0 10 10 10 10 0 % F
% Gly: 0 10 0 10 10 0 0 0 10 19 0 10 10 10 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 10 0 0 10 0 0 0 0 0 19 0 0 % K
% Leu: 0 0 0 0 0 0 10 10 19 0 0 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 19 0 0 0 0 0 0 0 10 37 0 % N
% Pro: 0 10 46 0 0 10 10 10 0 0 10 10 0 10 0 % P
% Gln: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 37 0 0 10 0 0 10 0 0 0 0 % R
% Ser: 10 0 10 0 10 55 19 19 46 46 46 0 37 19 19 % S
% Thr: 0 10 0 10 10 10 10 37 0 10 10 10 0 10 0 % T
% Val: 0 0 0 0 0 0 0 10 10 0 10 46 0 0 46 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _