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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP2
All Species:
20
Human Site:
S346
Identified Species:
36.67
UniProt:
P42575
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42575
NP_116764.2
452
50685
S346
G
S
P
G
C
E
E
S
D
A
G
K
E
K
L
Chimpanzee
Pan troglodytes
Q5IS54
277
31588
M182
D
S
G
V
D
D
D
M
A
C
H
K
I
P
V
Rhesus Macaque
Macaca mulatta
Q153Z0
421
47740
L326
A
D
T
H
G
Q
L
L
Q
S
S
I
C
N
D
Dog
Lupus familis
XP_848601
452
50347
S346
G
S
S
E
C
E
E
S
D
A
S
K
E
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P29594
452
50642
S346
Q
S
P
G
C
E
E
S
D
A
G
K
E
E
L
Rat
Rattus norvegicus
P55215
452
50709
S346
Q
S
P
G
C
E
E
S
D
A
G
K
E
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506482
767
84465
S664
A
S
P
G
C
E
E
S
D
A
G
K
E
E
M
Chicken
Gallus gallus
Q98943
424
47941
S317
D
S
P
G
C
E
E
S
D
A
N
K
E
E
N
Frog
Xenopus laevis
P55867
382
43370
A287
V
R
D
D
V
A
P
A
P
L
E
D
D
A
V
Zebra Danio
Brachydanio rerio
NP_001036160
435
49559
K328
E
R
D
N
R
E
K
K
E
E
K
E
R
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O01382
339
37345
A243
S
Y
K
I
P
V
H
A
D
F
L
I
A
Y
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
C397
P
L
F
N
F
L
G
C
V
R
P
Q
V
Q
Q
Sea Urchin
Strong. purpuratus
XP_799258
437
48470
D337
M
M
L
K
M
E
L
D
S
T
D
S
F
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.7
22.5
89.8
N.A.
89.5
89.5
N.A.
47.9
67
22.1
49.7
N.A.
25
N.A.
25.2
27.6
Protein Similarity:
100
36.2
42
92.6
N.A.
93.3
93.8
N.A.
51.2
76.9
40.9
64.3
N.A.
40.7
N.A.
42.3
47.5
P-Site Identity:
100
13.3
0
73.3
N.A.
86.6
86.6
N.A.
80
73.3
0
6.6
N.A.
6.6
N.A.
0
6.6
P-Site Similarity:
100
33.3
13.3
80
N.A.
93.3
93.3
N.A.
93.3
80
20
33.3
N.A.
13.3
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
8
0
16
8
47
0
0
8
16
0
% A
% Cys:
0
0
0
0
47
0
0
8
0
8
0
0
8
0
0
% C
% Asp:
16
8
16
8
8
8
8
8
54
0
8
8
8
0
8
% D
% Glu:
8
0
0
8
0
62
47
0
8
8
8
8
47
47
0
% E
% Phe:
0
0
8
0
8
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
16
0
8
39
8
0
8
0
0
0
31
0
0
0
0
% G
% His:
0
0
0
8
0
0
8
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
16
8
0
0
% I
% Lys:
0
0
8
8
0
0
8
8
0
0
8
54
0
8
0
% K
% Leu:
0
8
8
0
0
8
16
8
0
8
8
0
0
0
31
% L
% Met:
8
8
0
0
8
0
0
8
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
16
0
0
0
0
0
0
8
0
0
8
8
% N
% Pro:
8
0
39
0
8
0
8
0
8
0
8
0
0
8
0
% P
% Gln:
16
0
0
0
0
8
0
0
8
0
0
8
0
8
8
% Q
% Arg:
0
16
0
0
8
0
0
0
0
8
0
0
8
0
8
% R
% Ser:
8
54
8
0
0
0
0
47
8
8
16
8
0
0
16
% S
% Thr:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
8
0
0
8
8
8
0
0
8
0
0
0
8
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _