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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELZ
All Species:
21.52
Human Site:
S1852
Identified Species:
52.59
UniProt:
P42694
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42694
NP_055692
1942
218970
S1852
K
S
E
N
L
E
V
S
S
S
F
N
Y
S
V
Chimpanzee
Pan troglodytes
XP_001163943
1942
218960
S1852
K
S
E
N
L
E
V
S
S
S
F
N
Y
S
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850742
1944
219228
S1854
K
S
E
N
L
E
V
S
S
S
F
N
Y
N
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6DFV5
1964
219862
S1874
K
P
E
S
G
E
V
S
S
S
F
N
Y
S
M
Rat
Rattus norvegicus
NP_001099318
1964
220210
S1874
K
P
D
S
G
E
V
S
S
S
F
N
Y
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510313
1935
219682
P1845
K
P
E
S
L
Q
L
P
N
S
F
N
Y
N
V
Chicken
Gallus gallus
XP_415679
1941
220273
S1852
K
T
E
N
I
Q
L
S
N
S
F
N
Y
S
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NYU2
1860
208014
A1773
P
P
H
P
A
S
A
A
S
L
Q
H
H
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_996084
2103
230272
P2011
Q
A
M
A
P
S
V
P
H
S
E
A
A
N
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780726
1219
136539
L1138
S
L
S
S
Q
E
S
L
P
S
P
S
S
P
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
95.8
N.A.
90.7
90.8
N.A.
86.1
85.7
N.A.
62.4
N.A.
34.1
N.A.
N.A.
30
Protein Similarity:
100
99.6
N.A.
97.8
N.A.
94.8
94.5
N.A.
92.6
92.2
N.A.
73.8
N.A.
50.1
N.A.
N.A.
41.2
P-Site Identity:
100
100
N.A.
93.3
N.A.
73.3
73.3
N.A.
53.3
66.6
N.A.
6.6
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
86.6
86.6
N.A.
86.6
100
N.A.
26.6
N.A.
33.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
10
0
10
10
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
60
0
0
60
0
0
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
70
0
0
0
0
% F
% Gly:
0
0
0
0
20
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
10
0
0
0
0
0
10
0
0
10
10
0
10
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
70
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
40
0
20
10
0
10
0
0
0
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
40
0
0
0
0
20
0
0
70
0
30
0
% N
% Pro:
10
40
0
10
10
0
0
20
10
0
10
0
0
10
0
% P
% Gln:
10
0
0
0
10
20
0
0
0
0
10
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
30
10
40
0
20
10
60
60
90
0
10
10
50
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
60
0
0
0
0
0
0
0
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
70
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _