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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELZ
All Species:
21.21
Human Site:
S1883
Identified Species:
51.85
UniProt:
P42694
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42694
NP_055692
1942
218970
S1883
A
E
S
A
N
S
S
S
P
Q
S
S
A
G
G
Chimpanzee
Pan troglodytes
XP_001163943
1942
218960
S1883
A
E
S
A
N
S
S
S
P
Q
S
S
A
G
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850742
1944
219228
S1885
V
E
S
A
N
S
S
S
Q
Q
S
S
G
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q6DFV5
1964
219862
S1905
A
E
S
A
N
C
S
S
Q
Q
S
P
A
G
S
Rat
Rattus norvegicus
NP_001099318
1964
220210
S1905
A
E
S
A
N
S
S
S
Q
Q
S
P
A
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510313
1935
219682
S1876
V
E
P
N
N
N
S
S
Q
Q
S
V
S
G
N
Chicken
Gallus gallus
XP_415679
1941
220273
S1882
I
M
E
S
N
S
T
S
Q
Q
N
A
G
G
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NYU2
1860
208014
T1800
D
P
G
G
G
G
N
T
S
P
A
G
H
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_996084
2103
230272
G2037
Y
A
A
V
L
S
Q
G
P
Q
A
V
V
G
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780726
1219
136539
K1164
S
T
S
P
T
N
F
K
D
D
G
K
P
S
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
95.8
N.A.
90.7
90.8
N.A.
86.1
85.7
N.A.
62.4
N.A.
34.1
N.A.
N.A.
30
Protein Similarity:
100
99.6
N.A.
97.8
N.A.
94.8
94.5
N.A.
92.6
92.2
N.A.
73.8
N.A.
50.1
N.A.
N.A.
41.2
P-Site Identity:
100
100
N.A.
73.3
N.A.
73.3
80
N.A.
46.6
33.3
N.A.
0
N.A.
33.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
N.A.
73.3
N.A.
73.3
80
N.A.
60
60
N.A.
20
N.A.
46.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
10
10
50
0
0
0
0
0
0
20
10
40
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% D
% Glu:
0
60
10
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
10
10
0
10
0
0
10
10
20
80
30
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
10
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
10
70
20
10
0
0
0
10
0
0
0
10
% N
% Pro:
0
10
10
10
0
0
0
0
30
10
0
20
10
10
0
% P
% Gln:
0
0
0
0
0
0
10
0
50
80
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
60
10
0
60
60
70
10
0
60
30
10
10
40
% S
% Thr:
0
10
0
0
10
0
10
10
0
0
0
0
0
0
0
% T
% Val:
20
0
0
10
0
0
0
0
0
0
0
20
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _