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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFR All Species: 36.97
Human Site: S206 Identified Species: 58.1
UniProt: P42898 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42898 NP_005948.3 656 74597 S206 K G H P E A G S F E A D L K H
Chimpanzee Pan troglodytes XP_001141362 697 78964 S247 K G H P E A G S F E A D L K H
Rhesus Macaque Macaca mulatta XP_001105188 697 79008 S247 K G H P E A G S F E A D L K H
Dog Lupus familis XP_535405 780 87445 S331 K G H P D A G S F E A D L K Y
Cat Felis silvestris
Mouse Mus musculus Q9WU20 654 74631 S205 R G H P D A E S F E D D L K H
Rat Rattus norvegicus XP_342976 695 78719 S246 K G H P D A E S F E D D L K H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516302 646 73079 S203 K G H P E A E S F E A D L Q H
Chicken Gallus gallus XP_417645 508 58330 I84 N L I S S F I I T Q L F F R P
Frog Xenopus laevis NP_001080092 643 73624 S200 R G H P D A E S Y D Q D L K H
Zebra Danio Brachydanio rerio NP_001121727 656 74637 S206 T G H P E A E S Y E D D L R H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17693 663 75468 S219 L G H P Q A P S Y K A D L M Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002310366 608 67799 D185 D G F A T P E D Y Q K D L A Y
Maize Zea mays Q9SE94 593 66410 E170 G E G G A T L E A Y S N D L A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SE60 592 66270 P169 E A D G L A T P E S Y Q S D L
Baker's Yeast Sacchar. cerevisiae P53128 600 68542 Q177 L D L E Y L K Q K I D A G G D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.9 91.9 76.4 N.A. 89.9 83.8 N.A. 85 64.9 79.2 77.2 N.A. N.A. N.A. 46.4 N.A.
Protein Similarity: 100 94.1 93.1 80.7 N.A. 95.1 89.7 N.A. 92.5 71.4 88.5 87.5 N.A. N.A. N.A. 67.7 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 73.3 80 N.A. 86.6 0 60 66.6 N.A. N.A. N.A. 53.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 93.3 13.3 86.6 80 N.A. N.A. N.A. 80 N.A.
Percent
Protein Identity: 43.4 41.7 N.A. 41 38.7 N.A.
Protein Similarity: 60 59.1 N.A. 58.8 57.3 N.A.
P-Site Identity: 20 0 N.A. 6.6 0 N.A.
P-Site Similarity: 40 13.3 N.A. 13.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 7 74 0 0 7 0 40 7 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 7 0 27 0 0 7 0 7 27 74 7 7 7 % D
% Glu: 7 7 0 7 34 0 40 7 7 54 0 0 0 0 0 % E
% Phe: 0 0 7 0 0 7 0 0 47 0 0 7 7 0 0 % F
% Gly: 7 74 7 14 0 0 27 0 0 0 0 0 7 7 0 % G
% His: 0 0 67 0 0 0 0 0 0 0 0 0 0 0 54 % H
% Ile: 0 0 7 0 0 0 7 7 0 7 0 0 0 0 0 % I
% Lys: 40 0 0 0 0 0 7 0 7 7 7 0 0 47 0 % K
% Leu: 14 7 7 0 7 7 7 0 0 0 7 0 74 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 67 0 7 7 7 0 0 0 0 0 0 7 % P
% Gln: 0 0 0 0 7 0 0 7 0 14 7 7 0 7 0 % Q
% Arg: 14 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % R
% Ser: 0 0 0 7 7 0 0 67 0 7 7 0 7 0 0 % S
% Thr: 7 0 0 0 7 7 7 0 7 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 27 7 7 0 0 0 20 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _