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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFR All Species: 35.15
Human Site: S440 Identified Species: 55.24
UniProt: P42898 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42898 NP_005948.3 656 74597 S440 E V F V L Y L S G E P N R N G
Chimpanzee Pan troglodytes XP_001141362 697 78964 S481 E V F V L Y L S G E P N R N G
Rhesus Macaque Macaca mulatta XP_001105188 697 79008 S481 E V F V L Y L S G E P N R N G
Dog Lupus familis XP_535405 780 87445 S565 E V F A R Y L S G E P N Q H G
Cat Felis silvestris
Mouse Mus musculus Q9WU20 654 74631 S439 E V F E H Y L S G E P N R H G
Rat Rattus norvegicus XP_342976 695 78719 S480 E V F E H Y L S G E P N R H G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516302 646 73079 S437 E V F A Y Y L S G E P N Q N G
Chicken Gallus gallus XP_417645 508 58330 G306 T G E P N K N G H R V T C M P
Frog Xenopus laevis NP_001080092 643 73624 S434 E V F T Y Y I S G E P N P N G
Zebra Danio Brachydanio rerio NP_001121727 656 74637 T440 E V F T N Y I T G Q T N R S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17693 663 75468 T454 R V F I N Y I T Q A P N A D G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002310366 608 67799 D407 S P L K S V E D I Y E K F K V
Maize Zea mays Q9SE94 593 66410 E392 A V P L K S V E D I S E R F T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SE60 592 66270 I391 W V V P L K S I E D V Q E K F
Baker's Yeast Sacchar. cerevisiae P53128 600 68542 F399 T S I N D V A F L V I N Y L N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.9 91.9 76.4 N.A. 89.9 83.8 N.A. 85 64.9 79.2 77.2 N.A. N.A. N.A. 46.4 N.A.
Protein Similarity: 100 94.1 93.1 80.7 N.A. 95.1 89.7 N.A. 92.5 71.4 88.5 87.5 N.A. N.A. N.A. 67.7 N.A.
P-Site Identity: 100 100 100 73.3 N.A. 80 80 N.A. 80 0 73.3 53.3 N.A. N.A. N.A. 40 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. 86.6 0 80 80 N.A. N.A. N.A. 66.6 N.A.
Percent
Protein Identity: 43.4 41.7 N.A. 41 38.7 N.A.
Protein Similarity: 60 59.1 N.A. 58.8 57.3 N.A.
P-Site Identity: 0 13.3 N.A. 13.3 6.6 N.A.
P-Site Similarity: 0 26.6 N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 14 0 0 7 0 0 7 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 0 0 0 7 0 0 7 7 7 0 0 0 7 0 % D
% Glu: 60 0 7 14 0 0 7 7 7 54 7 7 7 0 0 % E
% Phe: 0 0 67 0 0 0 0 7 0 0 0 0 7 7 7 % F
% Gly: 0 7 0 0 0 0 0 7 60 0 0 0 0 0 67 % G
% His: 0 0 0 0 14 0 0 0 7 0 0 0 0 20 0 % H
% Ile: 0 0 7 7 0 0 20 7 7 7 7 0 0 0 0 % I
% Lys: 0 0 0 7 7 14 0 0 0 0 0 7 0 14 0 % K
% Leu: 0 0 7 7 27 0 47 0 7 0 0 0 0 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 7 20 0 7 0 0 0 0 74 0 34 7 % N
% Pro: 0 7 7 14 0 0 0 0 0 0 60 0 7 0 7 % P
% Gln: 0 0 0 0 0 0 0 0 7 7 0 7 14 0 0 % Q
% Arg: 7 0 0 0 7 0 0 0 0 7 0 0 47 0 0 % R
% Ser: 7 7 0 0 7 7 7 54 0 0 7 0 0 7 0 % S
% Thr: 14 0 0 14 0 0 0 14 0 0 7 7 0 0 7 % T
% Val: 0 80 7 20 0 14 7 0 0 7 14 0 0 0 7 % V
% Trp: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 14 67 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _