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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
36.06
Human Site:
S518
Identified Species:
56.67
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
S518
A
Y
L
E
F
F
T
S
R
E
T
A
E
A
L
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
S559
A
Y
L
E
F
F
T
S
R
E
T
A
E
A
L
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
S559
A
Y
L
E
F
F
T
S
R
E
T
A
E
A
L
Dog
Lupus familis
XP_535405
780
87445
S643
A
Y
L
E
F
F
T
S
R
E
T
V
G
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
S517
A
Y
L
E
F
F
T
S
R
E
T
V
E
A
L
Rat
Rattus norvegicus
XP_342976
695
78719
S558
A
Y
L
E
F
F
T
S
R
E
T
V
E
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
S515
A
Y
L
E
F
F
T
S
S
E
T
V
A
A
L
Chicken
Gallus gallus
XP_417645
508
58330
A383
T
S
N
E
I
V
T
A
L
L
K
V
L
K
K
Frog
Xenopus laevis
NP_001080092
643
73624
S512
A
Y
L
E
F
F
T
S
S
E
M
V
S
A
L
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
S518
A
Y
L
E
F
F
T
S
S
E
N
V
T
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
T534
A
Y
L
E
C
F
M
T
A
E
L
S
D
K
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
L484
Y
V
Y
Q
K
A
Y
L
E
F
F
C
S
K
E
Maize
Zea mays
Q9SE94
593
66410
Y469
G
Y
V
Y
Q
K
A
Y
L
E
F
F
C
A
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
A468
G
G
Y
V
Y
Q
K
A
Y
L
E
F
F
C
S
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
L476
K
Q
Y
L
E
F
M
L
P
K
T
K
L
P
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
80
13.3
73.3
73.3
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
80
20
73.3
73.3
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
20
N.A.
0
13.3
N.A.
P-Site Similarity:
6.6
26.6
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
67
0
0
0
0
7
7
14
7
0
0
20
7
67
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
7
7
7
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
0
0
74
7
0
0
0
7
74
7
0
34
0
7
% E
% Phe:
0
0
0
0
60
74
0
0
0
7
14
14
7
0
0
% F
% Gly:
14
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
7
7
7
0
0
7
7
7
0
20
20
% K
% Leu:
0
0
67
7
0
0
0
14
14
14
7
0
14
0
67
% L
% Met:
0
0
0
0
0
0
14
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% P
% Gln:
0
7
0
7
7
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
40
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
60
20
0
0
7
14
0
7
% S
% Thr:
7
0
0
0
0
0
67
7
0
0
54
0
7
0
0
% T
% Val:
0
7
7
7
0
7
0
0
0
0
0
47
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
74
20
7
7
0
7
7
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _