Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFR All Species: 36.06
Human Site: S518 Identified Species: 56.67
UniProt: P42898 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42898 NP_005948.3 656 74597 S518 A Y L E F F T S R E T A E A L
Chimpanzee Pan troglodytes XP_001141362 697 78964 S559 A Y L E F F T S R E T A E A L
Rhesus Macaque Macaca mulatta XP_001105188 697 79008 S559 A Y L E F F T S R E T A E A L
Dog Lupus familis XP_535405 780 87445 S643 A Y L E F F T S R E T V G A L
Cat Felis silvestris
Mouse Mus musculus Q9WU20 654 74631 S517 A Y L E F F T S R E T V E A L
Rat Rattus norvegicus XP_342976 695 78719 S558 A Y L E F F T S R E T V E A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516302 646 73079 S515 A Y L E F F T S S E T V A A L
Chicken Gallus gallus XP_417645 508 58330 A383 T S N E I V T A L L K V L K K
Frog Xenopus laevis NP_001080092 643 73624 S512 A Y L E F F T S S E M V S A L
Zebra Danio Brachydanio rerio NP_001121727 656 74637 S518 A Y L E F F T S S E N V T A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17693 663 75468 T534 A Y L E C F M T A E L S D K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002310366 608 67799 L484 Y V Y Q K A Y L E F F C S K E
Maize Zea mays Q9SE94 593 66410 Y469 G Y V Y Q K A Y L E F F C A K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SE60 592 66270 A468 G G Y V Y Q K A Y L E F F C S
Baker's Yeast Sacchar. cerevisiae P53128 600 68542 L476 K Q Y L E F M L P K T K L P K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.9 91.9 76.4 N.A. 89.9 83.8 N.A. 85 64.9 79.2 77.2 N.A. N.A. N.A. 46.4 N.A.
Protein Similarity: 100 94.1 93.1 80.7 N.A. 95.1 89.7 N.A. 92.5 71.4 88.5 87.5 N.A. N.A. N.A. 67.7 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 80 13.3 73.3 73.3 N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 80 20 73.3 73.3 N.A. N.A. N.A. 66.6 N.A.
Percent
Protein Identity: 43.4 41.7 N.A. 41 38.7 N.A.
Protein Similarity: 60 59.1 N.A. 58.8 57.3 N.A.
P-Site Identity: 0 20 N.A. 0 13.3 N.A.
P-Site Similarity: 6.6 26.6 N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 67 0 0 0 0 7 7 14 7 0 0 20 7 67 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 7 7 7 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 0 74 7 0 0 0 7 74 7 0 34 0 7 % E
% Phe: 0 0 0 0 60 74 0 0 0 7 14 14 7 0 0 % F
% Gly: 14 7 0 0 0 0 0 0 0 0 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 7 0 0 0 7 7 7 0 0 7 7 7 0 20 20 % K
% Leu: 0 0 67 7 0 0 0 14 14 14 7 0 14 0 67 % L
% Met: 0 0 0 0 0 0 14 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % P
% Gln: 0 7 0 7 7 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 40 0 0 0 0 0 0 % R
% Ser: 0 7 0 0 0 0 0 60 20 0 0 7 14 0 7 % S
% Thr: 7 0 0 0 0 0 67 7 0 0 54 0 7 0 0 % T
% Val: 0 7 7 7 0 7 0 0 0 0 0 47 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 74 20 7 7 0 7 7 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _