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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFR All Species: 36.06
Human Site: S605 Identified Species: 56.67
UniProt: P42898 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42898 NP_005948.3 656 74597 S605 L Y E E E S P S R T I I Q Y I
Chimpanzee Pan troglodytes XP_001141362 697 78964 S646 L Y E E E S P S R T I I Q Y I
Rhesus Macaque Macaca mulatta XP_001105188 697 79008 S646 L Y E E E S P S R T I I Q Y I
Dog Lupus familis XP_535405 780 87445 S730 L Y E E E S P S R M I I Q Y I
Cat Felis silvestris
Mouse Mus musculus Q9WU20 654 74631 S604 L Y E E E S P S R M I I Q Y I
Rat Rattus norvegicus XP_342976 695 78719 S645 L Y E E E S P S R M I I Q Y I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516302 646 73079 S602 L Y E E E S P S R M I I Q Y I
Chicken Gallus gallus XP_417645 508 58330 R465 Y E E E S P S R M I I Q Y I H
Frog Xenopus laevis NP_001080092 643 73624 S599 L Y E E E S P S R M I I Q Y I
Zebra Danio Brachydanio rerio NP_001121727 656 74637 S605 L Y E D E S P S R M I I Q Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17693 663 75468 K619 Q W G D F Y P K E S K S Y G V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002310366 608 67799 A566 E I W S R G W A S L Y P E G D
Maize Zea mays Q9SE94 593 66410 W551 F E I W T R G W G C M F P E G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SE60 592 66270 S550 A F E I W S R S W A N L Y P E
Baker's Yeast Sacchar. cerevisiae P53128 600 68542 N558 N E W K L N M N K Y D K P H S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.9 91.9 76.4 N.A. 89.9 83.8 N.A. 85 64.9 79.2 77.2 N.A. N.A. N.A. 46.4 N.A.
Protein Similarity: 100 94.1 93.1 80.7 N.A. 95.1 89.7 N.A. 92.5 71.4 88.5 87.5 N.A. N.A. N.A. 67.7 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 93.3 20 93.3 86.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 93.3 20 93.3 93.3 N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: 43.4 41.7 N.A. 41 38.7 N.A.
Protein Similarity: 60 59.1 N.A. 58.8 57.3 N.A.
P-Site Identity: 0 0 N.A. 20 0 N.A.
P-Site Similarity: 13.3 6.6 N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 7 0 7 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 0 0 0 14 0 0 0 0 0 0 7 0 0 0 7 % D
% Glu: 7 20 74 60 60 0 0 0 7 0 0 0 7 7 7 % E
% Phe: 7 7 0 0 7 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 0 0 7 0 0 7 7 0 7 0 0 0 0 14 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % H
% Ile: 0 7 7 7 0 0 0 0 0 7 67 60 0 7 60 % I
% Lys: 0 0 0 7 0 0 0 7 7 0 7 7 0 0 0 % K
% Leu: 60 0 0 0 7 0 0 0 0 7 0 7 0 0 0 % L
% Met: 0 0 0 0 0 0 7 0 7 40 7 0 0 0 0 % M
% Asn: 7 0 0 0 0 7 0 7 0 0 7 0 0 0 0 % N
% Pro: 0 0 0 0 0 7 67 0 0 0 0 7 14 7 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 7 60 0 0 % Q
% Arg: 0 0 0 0 7 7 7 7 60 0 0 0 0 0 0 % R
% Ser: 0 0 0 7 7 67 7 67 7 7 0 7 0 0 7 % S
% Thr: 0 0 0 0 7 0 0 0 0 20 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 7 14 7 7 0 7 7 7 0 0 0 0 0 0 % W
% Tyr: 7 60 0 0 0 7 0 0 0 7 7 0 20 60 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _