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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
6.06
Human Site:
S9
Identified Species:
9.52
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
S9
V
N
E
A
R
G
N
S
S
L
N
P
C
L
E
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
S50
V
N
E
A
R
G
N
S
S
L
N
P
C
L
E
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
D50
V
N
E
A
R
G
N
D
S
L
N
P
C
L
E
Dog
Lupus familis
XP_535405
780
87445
D51
K
E
P
R
G
D
G
D
G
G
P
T
P
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
S8
M
V
N
E
A
R
G
S
G
S
P
N
P
R
S
Rat
Rattus norvegicus
XP_342976
695
78719
S49
M
S
N
E
A
R
R
S
G
S
P
S
P
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
G9
V
N
E
A
A
S
S
G
S
R
R
S
S
S
S
Chicken
Gallus gallus
XP_417645
508
58330
Frog
Xenopus laevis
NP_001080092
643
73624
D8
M
V
N
A
N
S
S
D
S
G
T
A
S
C
S
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
G9
V
N
Q
R
A
D
V
G
W
H
S
K
S
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
I16
V
I
E
S
H
G
T
I
K
K
I
D
S
L
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
E9
K
V
I
D
K
I
R
E
A
A
G
G
G
G
D
Maize
Zea mays
Q9SE94
593
66410
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
6.6
6.6
N.A.
33.3
0
13.3
13.3
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
100
100
93.3
0
N.A.
13.3
20
N.A.
40
0
26.6
26.6
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
0
N.A.
0
0
N.A.
P-Site Similarity:
20
0
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
34
27
0
0
0
7
7
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
20
7
0
% C
% Asp:
0
0
0
7
0
14
0
20
0
0
0
7
0
7
7
% D
% Glu:
0
7
34
14
0
0
0
7
0
0
0
0
0
0
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
27
14
14
20
14
7
7
7
7
0
% G
% His:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
7
7
0
0
7
0
7
0
0
7
0
0
0
0
% I
% Lys:
14
0
0
0
7
0
0
0
7
7
0
7
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
20
0
0
0
27
0
% L
% Met:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
34
20
0
7
0
20
0
0
0
20
7
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
20
20
20
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
14
20
14
14
0
0
7
7
0
0
20
0
% R
% Ser:
0
7
0
7
0
14
14
27
34
14
7
14
27
7
47
% S
% Thr:
0
0
0
0
0
0
7
0
0
0
7
7
0
0
0
% T
% Val:
40
20
0
0
0
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _