KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
26.36
Human Site:
T521
Identified Species:
41.43
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
T521
E
F
F
T
S
R
E
T
A
E
A
L
L
Q
V
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
T562
E
F
F
T
S
R
E
T
A
E
A
L
L
Q
V
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
T562
E
F
F
T
S
R
E
T
A
E
A
L
L
Q
V
Dog
Lupus familis
XP_535405
780
87445
T646
E
F
F
T
S
R
E
T
V
G
A
L
L
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
T520
E
F
F
T
S
R
E
T
V
E
A
L
L
Q
V
Rat
Rattus norvegicus
XP_342976
695
78719
T561
E
F
F
T
S
R
E
T
V
E
A
L
L
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
T518
E
F
F
T
S
S
E
T
V
A
A
L
L
K
V
Chicken
Gallus gallus
XP_417645
508
58330
K386
E
I
V
T
A
L
L
K
V
L
K
K
Y
E
L
Frog
Xenopus laevis
NP_001080092
643
73624
M515
E
F
F
T
S
S
E
M
V
S
A
L
I
K
V
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
N521
E
F
F
T
S
S
E
N
V
T
A
L
L
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
L537
E
C
F
M
T
A
E
L
S
D
K
L
I
Q
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
F487
Q
K
A
Y
L
E
F
F
C
S
K
E
K
L
N
Maize
Zea mays
Q9SE94
593
66410
F472
Y
Q
K
A
Y
L
E
F
F
C
A
K
E
K
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
E471
V
Y
Q
K
A
Y
L
E
F
F
C
S
K
D
K
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
T479
L
E
F
M
L
P
K
T
K
L
P
K
L
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
73.3
13.3
60
73.3
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
80
33.3
73.3
73.3
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
13.3
N.A.
0
20
N.A.
P-Site Similarity:
6.6
26.6
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
14
7
0
0
20
7
67
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
7
7
7
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
7
% D
% Glu:
74
7
0
0
0
7
74
7
0
34
0
7
7
7
0
% E
% Phe:
0
60
74
0
0
0
7
14
14
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
14
7
7
% I
% Lys:
0
7
7
7
0
0
7
7
7
0
20
20
14
20
7
% K
% Leu:
7
0
0
0
14
14
14
7
0
14
0
67
60
7
14
% L
% Met:
0
0
0
14
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% P
% Gln:
7
7
7
0
0
0
0
0
0
0
0
0
0
54
0
% Q
% Arg:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
60
20
0
0
7
14
0
7
0
0
0
% S
% Thr:
0
0
0
67
7
0
0
54
0
7
0
0
0
0
0
% T
% Val:
7
0
7
0
0
0
0
0
47
0
0
0
0
0
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
7
7
7
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _