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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
12.12
Human Site:
T647
Identified Species:
19.05
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
T647
L
E
L
L
N
R
P
T
Q
N
A
R
E
T
E
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
T688
L
E
L
V
N
R
P
T
Q
N
A
R
E
T
E
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
T688
L
E
L
L
N
R
P
T
Q
N
E
R
E
T
E
Dog
Lupus familis
XP_535405
780
87445
S772
F
E
L
L
K
G
P
S
P
E
R
E
A
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
P646
F
E
L
L
N
R
H
P
T
E
R
E
T
Q
A
Rat
Rattus norvegicus
XP_342976
695
78719
T687
F
E
L
L
N
R
H
T
T
K
K
E
A
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
F637
W
Q
V
V
E
D
T
F
K
L
L
N
E
P
A
Chicken
Gallus gallus
XP_417645
508
58330
F499
W
Q
V
V
D
D
T
F
E
L
L
N
S
P
P
Frog
Xenopus laevis
NP_001080092
643
73624
K635
Q
V
I
E
D
T
F
K
E
H
D
R
P
T
D
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
Q647
F
A
L
L
D
S
S
Q
V
P
Q
Q
E
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
Q655
S
V
L
F
D
V
L
Q
K
A
L
D
E
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
D600
D
N
D
Y
I
H
G
D
I
F
A
V
F
A
E
Maize
Zea mays
Q9SE94
593
66410
G585
V
D
N
D
Y
V
Q
G
D
L
F
A
A
F
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
N584
L
V
D
N
N
Y
I
N
G
D
I
F
S
V
F
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
Q592
D
Y
I
S
P
D
D
Q
I
H
S
I
L
L
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
93.3
93.3
26.6
N.A.
33.3
40
N.A.
6.6
0
13.3
20
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
93.3
33.3
N.A.
33.3
40
N.A.
33.3
33.3
46.6
33.3
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
13.3
0
N.A.
13.3
0
N.A.
P-Site Similarity:
13.3
20
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
7
20
7
20
14
27
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
14
7
27
20
7
7
7
7
7
7
0
0
7
% D
% Glu:
0
40
0
7
7
0
0
0
14
14
7
20
40
7
27
% E
% Phe:
27
0
0
7
0
0
7
14
0
7
7
7
7
7
7
% F
% Gly:
0
0
0
0
0
7
7
7
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
7
14
0
0
14
0
0
0
0
0
% H
% Ile:
0
0
14
0
7
0
7
0
14
0
7
7
0
0
0
% I
% Lys:
0
0
0
0
7
0
0
7
14
7
7
0
0
0
14
% K
% Leu:
27
0
54
40
0
0
7
0
0
20
20
0
7
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
7
40
0
0
7
0
20
0
14
0
0
7
% N
% Pro:
0
0
0
0
7
0
27
7
7
7
0
0
7
14
7
% P
% Gln:
7
14
0
0
0
0
7
20
20
0
7
7
0
14
0
% Q
% Arg:
0
0
0
0
0
34
0
0
0
0
14
27
0
0
0
% R
% Ser:
7
0
0
7
0
7
7
7
0
0
7
0
14
0
7
% S
% Thr:
0
0
0
0
0
7
14
27
14
0
0
0
7
27
0
% T
% Val:
7
20
14
20
0
14
0
0
7
0
0
7
0
7
0
% V
% Trp:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
7
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _