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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFR
All Species:
25.15
Human Site:
Y174
Identified Species:
39.52
UniProt:
P42898
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42898
NP_005948.3
656
74597
Y174
E
E
E
G
G
F
N
Y
A
V
D
L
V
K
H
Chimpanzee
Pan troglodytes
XP_001141362
697
78964
Y215
E
E
E
G
G
F
N
Y
A
V
D
L
V
K
H
Rhesus Macaque
Macaca mulatta
XP_001105188
697
79008
Y215
E
E
E
G
G
F
N
Y
A
V
D
L
V
K
H
Dog
Lupus familis
XP_535405
780
87445
Y299
V
V
E
G
G
F
S
Y
A
A
D
L
V
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU20
654
74631
Y173
A
E
E
G
G
F
S
Y
A
T
D
L
V
K
H
Rat
Rattus norvegicus
XP_342976
695
78719
Y214
A
E
E
G
G
F
S
Y
A
T
D
L
V
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516302
646
73079
H171
E
E
E
G
G
F
N
H
A
V
D
L
V
K
H
Chicken
Gallus gallus
XP_417645
508
58330
R52
E
R
L
R
E
K
M
R
R
R
Q
D
S
G
D
Frog
Xenopus laevis
NP_001080092
643
73624
Y168
E
E
A
E
G
F
N
Y
A
V
D
L
V
K
H
Zebra Danio
Brachydanio rerio
NP_001121727
656
74637
F174
E
E
D
G
G
F
N
F
A
T
D
L
V
K
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17693
663
75468
R187
L
E
D
T
H
Q
F
R
A
L
D
M
I
R
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002310366
608
67799
R153
L
D
L
V
K
H
I
R
S
K
Y
G
D
Y
F
Maize
Zea mays
Q9SE94
593
66410
I138
A
L
D
L
V
Q
H
I
R
A
K
Y
G
D
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SE60
592
66270
H137
C
A
L
D
L
V
N
H
I
R
S
K
Y
G
D
Baker's Yeast
Sacchar. cerevisiae
P53128
600
68542
Y145
I
K
Y
I
K
S
K
Y
G
D
H
F
A
I
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
91.9
76.4
N.A.
89.9
83.8
N.A.
85
64.9
79.2
77.2
N.A.
N.A.
N.A.
46.4
N.A.
Protein Similarity:
100
94.1
93.1
80.7
N.A.
95.1
89.7
N.A.
92.5
71.4
88.5
87.5
N.A.
N.A.
N.A.
67.7
N.A.
P-Site Identity:
100
100
100
66.6
N.A.
80
80
N.A.
93.3
6.6
86.6
80
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
100
100
80
N.A.
86.6
86.6
N.A.
100
6.6
86.6
93.3
N.A.
N.A.
N.A.
53.3
N.A.
Percent
Protein Identity:
43.4
41.7
N.A.
41
38.7
N.A.
Protein Similarity:
60
59.1
N.A.
58.8
57.3
N.A.
P-Site Identity:
0
0
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
20
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
7
7
0
0
0
0
0
67
14
0
0
7
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
20
7
0
0
0
0
0
7
67
7
7
7
14
% D
% Glu:
47
60
47
7
7
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
60
7
7
0
0
0
7
0
0
7
% F
% Gly:
0
0
0
54
60
0
0
0
7
0
0
7
7
14
7
% G
% His:
0
0
0
0
7
7
7
14
0
0
7
0
0
0
60
% H
% Ile:
7
0
0
7
0
0
7
7
7
0
0
0
7
7
0
% I
% Lys:
0
7
0
0
14
7
7
0
0
7
7
7
0
54
0
% K
% Leu:
14
7
20
7
7
0
0
0
0
7
0
60
0
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
14
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
7
0
7
0
0
0
20
14
14
0
0
0
14
0
% R
% Ser:
0
0
0
0
0
7
20
0
7
0
7
0
7
0
0
% S
% Thr:
0
0
0
7
0
0
0
0
0
20
0
0
0
0
0
% T
% Val:
7
7
0
7
7
7
0
0
0
34
0
0
60
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
7
0
0
0
0
54
0
0
7
7
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _