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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GDF5
All Species:
20
Human Site:
Y177
Identified Species:
40
UniProt:
P43026
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43026
NP_000548.1
501
55411
Y177
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Chimpanzee
Pan troglodytes
XP_001164592
501
55399
Y177
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Rhesus Macaque
Macaca mulatta
XP_001099702
499
55239
Y175
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Dog
Lupus familis
XP_542974
499
55131
Y175
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Cat
Felis silvestris
Mouse
Mus musculus
P43027
495
54867
Y171
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Rat
Rattus norvegicus
Q6HA10
452
50994
S154
Q
K
Y
L
F
D
V
S
T
L
S
D
K
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511410
181
19862
Chicken
Gallus gallus
Q90752
405
46039
S129
H
H
E
E
H
L
E
S
V
P
G
P
S
E
A
Frog
Xenopus laevis
P25703
398
45557
E121
F
H
H
E
E
S
M
E
E
I
P
E
S
R
E
Zebra Danio
Brachydanio rerio
P85857
404
46271
D128
R
R
Q
T
Y
L
F
D
V
S
T
L
S
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07713
588
65849
D182
E
E
P
T
L
V
L
D
R
E
V
A
S
I
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P48969
461
51863
V155
F
N
Y
T
R
N
E
V
Q
A
V
S
Q
A
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.8
96.4
N.A.
91.2
46.7
N.A.
28.1
28.9
26.9
42.5
N.A.
25.3
N.A.
N.A.
24.1
Protein Similarity:
100
99.4
98.1
97
N.A.
92.6
62
N.A.
32.7
43.1
42.5
56.2
N.A.
40.8
N.A.
N.A.
40.7
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
0
6.6
6.6
0
N.A.
26.6
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
0
6.6
26.6
6.6
N.A.
46.6
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
0
9
0
50
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
17
0
0
0
9
42
9
50
% D
% Glu:
9
50
9
17
9
0
17
9
9
9
0
9
0
17
17
% E
% Phe:
17
0
0
0
9
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% G
% His:
50
17
9
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% I
% Lys:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
9
% K
% Leu:
0
0
0
9
50
17
50
0
0
9
42
9
0
0
0
% L
% Met:
0
0
0
42
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
9
% N
% Pro:
0
0
9
0
0
0
0
0
0
9
9
9
0
0
0
% P
% Gln:
9
0
9
0
0
0
0
0
9
0
0
0
9
0
0
% Q
% Arg:
9
9
0
0
9
0
0
0
50
0
0
0
0
9
0
% R
% Ser:
0
0
0
0
0
50
0
17
0
9
9
50
34
0
0
% S
% Thr:
0
0
0
25
0
0
0
0
9
42
9
0
0
0
0
% T
% Val:
0
0
0
0
0
9
9
9
17
0
17
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
59
0
9
0
0
42
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _